The anatomy of T-cell activation and tolerance

Anna Mondino; Alexander Khoruts; Marc K. Jenkins

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The anatomy of T-cell activation and tolerance

机译：T细胞活化与耐受性的解剖

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The mammalian im- mune system must specifically recognize and eliminate foreign invaders but refrain from damaging the host. This task is accomplished in part by the production of a large number of T lymphocytes, each bearing a different antigen receptor to match the enormous variety of antigens present in the microbial world. However, because antigen receptor diversity is gen- erated by a random mechanism, the im- mune system must tolerate the function of T lymphocytes that by chance express a self-reactive antigen receptor.

机译：哺乳动物的免疫系统必须专门识别并消除外来入侵者，但不要破坏宿主。这项任务部分通过产生大量T淋巴细胞来完成，每个T淋巴细胞带有不同的抗原受体，以匹配微生物世界中存在的多种抗原。但是，由于抗原受体的多样性是由随机机制产生的，因此免疫系统必须能够耐受偶然表达自身反应性抗原受体的T淋巴细胞的功能。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2245-2252|共8页
作者
Anna Mondino; Alexander Khoruts; Marc K. Jenkins;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells (Retraction of vol 69, pg 6256, 2009) [J] . Shafer-Weaver Kimberly A., Anderson Michael J., Draper Lauren J., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2016,第8期

机译：对小鼠前列腺肿瘤具有免疫力：持续提供T细胞帮助可防止CD8 T细胞耐受并激活肿瘤浸润的树突状细胞（第69卷，第6256页的撤回，2009年）
2. Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells. [J] . Shafer Weaver KA, Watkins SK, Anderson MJ Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第15期

机译：对鼠类前列腺肿瘤具有免疫力：持续提供T细胞有助于防止CD8 T细胞耐受并激活肿瘤浸润性树突状细胞。
3. Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells. [J] . Shafer Weaver KA, Watkins SK, Anderson MJ Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第15期

机译：对鼠类前列腺肿瘤具有免疫力：持续提供T细胞有助于防止CD8 T细胞耐受并激活肿瘤浸润性树突状细胞。
4. A NOVEL SCALABLE MANUFACTURING PLATFORM FOR T-CELL ACTIVATION AND EXPANSION IN ADOPTIVE T-CELL THERAPY [C] . Jian Ling Conference on advancing manufacture of cell and gene therapies . 2019

机译：适应性T细胞治疗中T细胞活化和扩展的新型可扩展制造平台
5. The acquisition of dendritic cell tolerance during malaria infection results in differential T-cell activation. [D] . Perry, James A. 2008

机译：疟疾感染期间树突状细胞耐受性的获得导致差异性T细胞活化。
6. The anatomy of T-cell activation and tolerance. [O] . A Mondino, A Khoruts, M K Jenkins 1996

机译：T细胞活化和耐受性的解剖。
7. The anatomy of T-cell activation and tolerance. [O] . Mondino, A, Khoruts, A, Jenkins, M K 1996

机译：T细胞活化和耐受性的解剖。

The anatomy of T-cell activation and tolerance

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