Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice

Jan A. Nolta; Mo A. Dao; Susie Wells

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Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice

机译：在免疫缺陷小鼠中植入后通过克隆分析证明了多能人类造血干细胞的转导

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Gene transduction of pluripotent human he- matopoietic stem cells (HSCs) is necessary for successful gene therapy of genetic disorders involving hematolymphoid cells. Evidence for transduction of pluripotent HSCs can be deduced from the demonstration of a retroviral vector integrated into the same cellular chromosomal DNA site in myeloid and lymphoid cells descended from a common HSC precursor.

机译：多能人类造血干细胞（HSC）的基因转导对于涉及血淋巴样细胞的遗传疾病的成功基因治疗是必要的。多能性HSC的转导证据可以通过将逆转录病毒载体整合到同一HSC前体的髓样和淋巴样细胞的同一细胞染色体DNA位点中来证明。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2414-2419|共6页
作者
Jan A. Nolta; Mo A. Dao; Susie Wells;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Recombinant AAV2 transduction of primitive human hematopoietic stem cells capable of serial engraftment in immune-deficient mice. [J] . Santat L, Paz H, Wong C, Proceedings of the National Academy of Sciences of the United States of America . 2005,第31期

机译：能够连续植入免疫缺陷小鼠的原始人类造血干细胞的重组AAV2转导。
2. Fibrogenic and angiogenic commitments of human induced pluripotent stem cells derived mesenchymal stem cells in connective tissue growth factor-delivering scaffold in an immune-deficient mice model [J] . Xu Ruodan, Dagnaes-Hansen Frederik, Wogensen Lise, Journal of biomedical materials research. Part B, Applied biomaterials. . 2018,第6期

机译：人诱导多能干细胞衍生间充质干细胞在免疫缺陷小鼠模型中的结缔组织生长因子递送支架中的间充质干细胞衍生间充质干细胞
3. Engraftment efficacy of human hematopoietic stem cells transplanted into NOD/SCID mice using two methods: intra-bone marrow transplantation of hematopoietic stem cells and intravenous co-transplantation with mesenchymal stem cells. [J] . Dae Seong Kim, Myoung Woo Lee, Yoo Hun Noh, Acta Haematologica . 2014,第3期

机译：使用两种方法将人造血干细胞移植入NOD / SCID小鼠的植入效力：造血干细胞的骨髓内移植和间充质干细胞的静脉共移植。
4. Enhancing hepatic functions of human induced pluripotent stem cells-derived hepatocytes and their engraftment in immunocompetent mice via 3D co-aggregation and encapsulation [C] . Wei Song, Minglin Ma World biomaterials congress . 2016

机译：通过3D共聚集和包囊增强人类诱导的多能干细胞衍生的肝细胞的肝功能及其在免疫活性小鼠中的移植
5. Nano-structural Analysis of Engrafted Human Induced Pluripotent Stem Cell-derived Cardiomyocytes in Mouse Hearts Using a Genetic-probe APEX2 [D] . Hatani, Takeshi 2019

机译：使用遗传探针APEX2在小鼠心脏中植入人类诱导的多能干细胞衍生的心肌细胞的纳米结构分析。
6. Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. [O] . J A Nolta, M A Dao, S Wells, 1996

机译：在免疫缺陷小鼠中植入后通过克隆分析证明了多能人类造血干细胞的转导。
7. Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice. [O] . Nolta, J A, Dao, M A, Wells, S, 1996

机译：在免疫缺陷小鼠中植入后，通过克隆分析证明了多能人类造血干细胞的转导。

Transduction of pluripotent human hematopoietic stem cells demonstrated by clonal analysis after engraftment in immune-deficient mice

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