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A long-range regulatory element of Hoxc8 identified by using the pClasper vector

机译:使用pClasper载体鉴定的Hoxc8的远程调控元件

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摘要

Hox genes are located in highly conserved clusters. The significance of this organization is unclear, but one possibility is that regulatory regions for individual genes are dispersed throughout the cluster and shared with other Hox genes. This hypothesis is supported by studies on several Hox genes in which even large genomic regions immediately surrounding the gene fail to direct the complete expression pattern in transgenic mice.
机译:Hox基因位于高度保守的簇中。该组织的意义尚不清楚,但一种可能性是单个基因的调控区分散在整个簇中并与其他Hox基因共享。对几个Hox基因的研究支持了这一假设,其中即使是紧邻该基因的大基因组区域也无法指导转基因小鼠的完整表达方式。

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