Least activation path for protein folding: Investigation of staphylococcal nuclease folding by stopped-flow circular dichroism

Z.-D. Su; M. T. Arooz; H. M. Chen

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Least activation path for protein folding: Investigation of staphylococcal nuclease folding by stopped-flow circular dichroism

机译：蛋白质折叠的最小激活途径：停流圆二色性研究葡萄球菌核酸酶折叠

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Is the pathway of protein folding determined by the relative stability of folding intermediates, or by the relative height of the activation barriers leading to these intermediates? This is a fundamental question for resolving the Levinthal paradox, which stated that protein folding by a random search mechanism would require a time too long to be plausible.

机译：蛋白质折叠的途径是由折叠中间体的相对稳定性还是由导致这些中间体的活化屏障的相对高度决定的？这是解决Levinthal悖论的一个基本问题，Levinthal悖论指出，通过随机搜索机制折叠蛋白质将需要很长的时间以至于难以置信。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2539-2544|共6页
作者
Z.-D. Su; M. T. Arooz; H. M. Chen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Kinetic folding and cis/trans prolyl isomerization of staphylococcal nuclease. A study by stopped-flow absorption, stopped-flow circular dichroism, and molecular dynamics simulations. [J] . Ikura T, Tsurupa GP, Kuwajima K Biochemistry . 1997,第21期

机译：葡萄球菌核酸酶的动力学折叠和顺式/反式脯氨酰异构化。通过停止流吸收，停止流圆二色性和分子动力学模拟进行的研究。
2. Partially Folded States of Staphylococcal Nuclease Highlight the Conserved Structural Hierarchy of OB-Fold Proteins [J] . Emma Watson, William M.Matousek, Evelyn L.Irimies Biochemistry . 2007,第33期

机译：部分折叠的葡萄球菌核酸酶的状态突出了ob折蛋白的保守结构等级
3. Parallel folding pathway of proline-free staphylococcal nuclease studied by the stopped-flow double-jump method [J] . KiyotoKamagata, KunihiroKuwajima Spectroscopy . 2003,第2a3期

机译：停止流双跳跃法研究无脯氨酸葡萄球菌核酸酶的平行折叠途径
4. Study of protein folding/unfolding structure mechanism of staphylococcal nuclease wild type and its mutant V66W by PEPS-HDX-ESI-MS [C] . Rohana Liyanage, Derek Pyland, Jackson O. Lay, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：蛋白质粘合剂野生型蛋白质折叠/展开结构机制及其蛋白酶蛋白酶β-eSI-MS的突变体V66W
5. Spectroscopic characterization of the reaction intermediates of the heme-thiolate proteins of cytochrome P450cam and Caldariomyces fumago chloroperoxidase and investingation of the structure and kinetics of hemecontaining proteins using magnetic circular dichroism and rapid-scan, stopped-flow spectroscopy. [D] . Collins, Daniel P. 2012

机译：光谱学表征细胞色素P450cam和富马卡德氏霉菌的氯过氧化物酶的血红素硫醇盐蛋白的反应中间体，并利用磁性圆二色性和快速扫描，停止流光谱学研究含血红素的蛋白的结构和动力学。
6. Least activation path for protein folding: investigation of staphylococcal nuclease folding by stopped-flow circular dichroism. [O] . Z D Su, M T Arooz, H M Chen, 1996

机译：蛋白质折叠的最小活化途径：通过停流圆二色性研究葡萄球菌核酸酶折叠。
7. Least activation path for protein folding: Investigation of staphylococcal nuclease folding by stopped-flow circular dichroism [O] . Su, ZD, Arooz, MT, Chen, HM, 1996

机译：蛋白质折叠的最小激活途径：停流圆二色性研究葡萄球菌核酸酶折叠

Least activation path for protein folding: Investigation of staphylococcal nuclease folding by stopped-flow circular dichroism

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