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Inositol 1,4,5-trisphosphate receptor subtype 3 in pancreatic islet cell secretory granules revisited

机译:胰岛细胞分泌颗粒中的肌醇1,4,5-三磷酸受体亚型3

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摘要

It has been reported that the inositol 1,4,5- trisphosphate receptor subtype 3 is expressed in islet cells and is localized to both insulin and somatostatin granules [Blon- del, O., Moody, M. M., Depaoli, A. M., Sharp, A. H., Ross, C. A., Swift, H. & Bell, G. I. (1994) Proc. Natl. Acad. Sci. USA 91, 7777-7781]. This subcellular localization was based on electron microscope immunocytochemistry using antibodies (affinity-purified polyclonal antiserum AB3) directed to a 15-residue peptide of rat inositol trisphosphate receptor sub- type 3.
机译:据报道,肌醇1,4,5-三磷酸受体3亚型在胰岛细胞中表达,并定位于胰岛素和生长抑素颗粒[Blondel,O.,Moody,MM,Depaoli,AM,Sharp,AH ,罗斯,加州,斯威夫特,H。和贝尔,GI(1994)美国国家科学院院刊。 Natl。学院科学美国91,7777-7781]。该亚细胞定位是基于电子显微镜免疫细胞化学,使用针对大鼠肌醇三磷酸受体亚型3的15个残基肽的抗体(亲和纯化的多克隆抗血清AB3)。

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