Pentameric subunit stoichiometry of a neuronal glutamate receptor

Antonio V. Ferrer-Montiel; Mauricio Montal

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pentameric subunit stoichiometry of a neuronal glutamate receptor

【24h】

Pentameric subunit stoichiometry of a neuronal glutamate receptor

机译：神经元谷氨酸受体的五聚体亚基化学计量

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Ionotropic glutamate receptors, neurotrans- mitter-activated ion channels that mediate excitatory synaptic transmission in the central nervous system, are oligomeric membrane proteins of unknown subunit stoichiometry. To determine the subunit stoichiometry we have used a functional assay based on the blockade of two -amino-3-hydroxy-5-methyl- 4-isoxazole propionate/kainate receptor subunit 1 (GluR1) mu- tant subunits selectively engineered to exhibit differential sen- sitivity to the open channel blockers phencyclidine and dizolci- pine (MK-801).

机译：离子型谷氨酸受体是介导中枢神经系统兴奋性突触传递的神经递质激活的离子通道，是化学计量未知的寡聚膜蛋白。为了确定亚基的化学计量，我们使用了一种功能测定法，该功能测定基于选择性地改造成能表现出不同感觉的两个氨基-氨基-3-羟基-5-甲基-4-异异唑丙酸酯/海藻酸酯受体亚基1（GluR1）突变亚基的阻滞作用-对开放通道阻断剂苯环利定和地佐西平（MK-801）的耐受性。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2741-2744|共4页
作者
Antonio V. Ferrer-Montiel; Mauricio Montal;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits. [J] . Drenan RM, Nashmi R, Imoukhuede P, Molecular pharmacology. . 2008,第1期

机译：含有荧光标记的α6和β3亚基的神经元烟碱型乙酰胆碱受体的亚细胞贩运，五聚体组装和亚基化学计量。
2. Exogenous glutamate enhances glutamate receptor subunit expression during selective neuronal injury in the ventral arcuate nucleus of postnatal mice. [J] . Hu L, Fernstrom JD, Goldsmith PC Neuroendocrinology: International Journal for Basic and Clinical Studies on Neuroendocrine Relationships . 1998,第2期

机译：外源谷氨酸在产后小鼠腹弓状核的选择性神经元损伤过程中增强了谷氨酸受体亚基的表达。
3. Pretty subunits all in a row: using concatenated subunit constructs to force the expression of receptors with defined subunit stoichiometry and spatial arrangement. [J] . White MM Molecular pharmacology. . 2006,第2期

机译：连续排列漂亮的亚基：使用串联的亚基构建体，以具有确定的亚基化学计量和空间排列的受体表达。
4. Two-step labeling allows analysis of neuronal AMPA-type glutamate receptors dynamics “beyond optical resolution limit” [C] . Kento Ojima, Mikiko Takato, Shigeki Kiyonaka 日本化学会春季年会講演予稿集 . 2018

机译：两步标记允许分析神经元AMPA型谷氨酸受体动态“超出光学分辨率限制”
5. Studies of neuronal nicotinic acetylcholine receptors in the rat pineal gland: A model for native receptors composed of alpha-3 and beta-4 subunits. [D] . Hernandez, Susan Carolyn. 2001

机译：大鼠松果体神经元烟碱乙酰胆碱受体的研究：由α-3和β-4亚基组成的天然受体的模型。
6. Pentameric subunit stoichiometry of a neuronal glutamate receptor. [O] . A V Ferrer-Montiel, M Montal 1996

机译：神经元谷氨酸受体的五聚体亚基化学计量。
7. Pentameric subunit stoichiometry of a neuronal glutamate receptor. [O] . Ferrer-Montiel, A V, Montal, M 1996

机译：神经元谷氨酸受体的五聚体亚基化学计量。

Pentameric subunit stoichiometry of a neuronal glutamate receptor

摘要

著录项

相似文献

相关主题

期刊订阅