In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression

Mark G. Frattini; Hock B. Lim; Laimonis A. Laimins

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In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression

机译：致癌人乳头瘤病毒的体外合成需要游离基因组才能实现分化依赖性晚期表达

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Human papillomavirus (HPV) types 16, 18, 31, and 51 are the etiologic agents of many anogenital cancers including those of the cervix. These "high risk" HPVs specif- ically target genital squamous epithelia, and their lytic life cycle is closely linked to epithelial differentiation. We have developed a genetic assay for HPV functions during patho- genesis using recircularized cloned HPV 31 genomes that were transfected together with a drug resistance marker into monolayer cultures of normal human foreskin keratinocytes, the natural host cell.

机译：16、18、31和51型人乳头瘤病毒（HPV）是许多肛门生殖器癌症（包括宫颈癌）的病原体。这些“高风险” HPV专门针对生殖器鳞状上皮细胞，其溶解生命周期与上皮细胞分化密切相关。我们已经开发出了一种使用重组的HPV 31循环基因组，对HPV在发病过程中的功能进行遗传检测的方法，该基因组与抗药性标记一起转染到正常人包皮角质形成细胞（天然宿主细胞）的单层培养物中。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3062-3067|共6页
作者
Mark G. Frattini; Hock B. Lim; Laimonis A. Laimins;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L1 capsid protein expression. [J] . Knight GL, Pugh AG, Yates E, Virology . 2011,第1期

机译：人乳头瘤病毒18型（HPV18）E1 ^ E4中的细胞周期蛋白结合基序对于与CDK-细胞周期蛋白复合物和角质形成细胞的G2 / M细胞周期停滞有关是必需的，但对于分化依赖性病毒基因组扩增或L1衣壳蛋白不是必需的表达。
2. ONCOGENIC HUMAN PAPILLOMAVIRUSES: High-Risk Human Papillomaviruses: Towards a Better Understanding of the Mechanisms of Viral Transformation, Latency and Immune-Escape [J] . A Cid Arregui, P Gariglio, T Kanda, The Open Virology Journal . 2017,第1期

机译：致癌性人类乳头瘤病毒：高危人类乳头瘤病毒：更好地理解病毒转化，潜伏期和免疫逃逸的机制
3. p16~(INK4a) Overexpression Is Not Linked to Oncogenic Human Papillomaviruses in Patients With High-Grade Urothelial Cancer Cells [J] . Eric Piaton, Jean-Sebastien Casalegno, Anne-Sophie Advenier, Cancer: A Journal of the American Cancer Society . 2014,第10期

机译：p16〜（INK4a）过度表达与高级别尿路上皮癌细胞患者的致癌人乳头瘤病毒无关
4. Expression of Cyclooxygenase (COX)-2 in Human Endometrial Adenocarcinoma Cell Line HEC-1B:An In Vitro Model of the Expression of COX-2 by Platelet-Activating Factor [C] . KOHJI MlYAZAKI, KOHJI FUKUNAGA, IQBAL MUNIR, International Symposium on the Cell and Molecular Biology of Endometrial Carcinoma . 2003

机译：环氧氧酶（COX）-2在人子宫内膜腺癌细胞系HEC-1B中的表达：血小板活化因子COX-2表达的体外模型
5. The role of E1^E4 in the differentiation-dependent life cycle of oncogenic human papillomaviruses. [D] . Wilson, Regina. 2005

机译：E1 ^ E4在致癌性人乳头瘤病毒的分化依赖性生命周期中的作用。
6. In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. [O] . M G Frattini, H B Lim, L A Laimins 1996

机译：致癌性人乳头瘤病毒的体外合成需要游离基因组用于分化依赖性晚期表达。
7. In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression. [O] . Frattini, M G, Lim, H B, Laimins, L A 1996

机译：致癌性人乳头瘤病毒的体外合成需要游离基因组用于分化依赖性晚期表达。

In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression

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