Successful expression of human factor IX following repeat administration of an adenoviral vector in mice

Johannes Walter; Qimin You; J. Nathan Hagstrom

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Successful expression of human factor IX following repeat administration of an adenoviral vector in mice

机译：在小鼠中反复施用腺病毒载体后成功表达人因子IX

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Adenoviral vectors can direct high-level ex- pression of a transgene, but, due to a host immune response to adenoviral antigens, expression is of limited duration, and repetitive administration has generally been unsuccessful. Exposure to foreign proteins beginning in the neonatal period may alter or ablate the immune response. We injected adult and neonatal (immunocompetent) CD-1 mice intravenously with an adenoviral vector expressing human blood coagula- tion factor IX.

机译：腺病毒载体可以指导转基因的高水平表达，但是由于宿主对腺病毒抗原的免疫反应，表达的持续时间有限，并且重复施用通常是不成功的。从新生儿期开始接触外源蛋白质可能会改变或消除免疫反应。我们用表达人凝血因子的腺病毒载体静脉注射成年和新生儿（具有免疫能力的）CD-1小鼠。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3056-3061|共6页
作者
Johannes Walter; Qimin You; J. Nathan Hagstrom;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. A study of gene transfer and expression of human clotting factor IX in Hemophilia B mice mediated by mini-adenoviral vector [J] . GAO Xiaobo, YE Chenbo, SHI Ding, Science in China. Series C, Life science . 2003,第6期

机译：微型腺病毒载体介导的血友病B小鼠基因转移及人类凝血因子IX表达的研究
2. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. [J] . Dai Y, Schwarz EM, Gu D, Proceedings of the National Academy of Sciences of the United States of America . 1995,第5期

机译：对包含因子IX基因的腺病毒载体的细胞和体液免疫反应：因子IX和载体抗原的耐受性允许长期表达。
3. Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice. [J] . Fields PA, Armstrong E, Hagstrom JN, Gene therapy . 2001,第5期

机译：静脉内施用缺失E1 / E3的腺病毒载体可诱导C57BL / 6小鼠对IX因子的耐受性。
4. High Levels of Human Factor IX Transgene Expression in Mice Increase Blood Procoagulant Activity [C] . M. A. Srour, J. Grupp, Th. Albert, Hemophilia Symposium . 2008

机译：小鼠中高水平的人体因子IX转基因表达增加血液探剂活性
5. Comparative analysis of human and nonhuman adenoviral vectors for gene delivery. [D] . Sharma, Anurag. 2009

机译：人类和非人类腺病毒载体用于基因递送的比较分析。
6. Successful expression of human factor IX following repeat administration of adenoviral vector in mice. [O] . J Walter, Q You, J N Hagstrom, 1996

机译：在小鼠中重复施用腺病毒载体后人因子IX的成功表达。
7. Successful expression of human factor IX following repeat administration of adenoviral vector in mice. [O] . Walter, J, You, Q, Hagstrom, J N, 1996

机译：在小鼠中重复施用腺病毒载体后，人因子IX的成功表达。
8. Transcription Activator Reprogramming Gene Therapy (TARGET) of Breast Cancer Cells with Adenoviral Vectors for Interferon Regulatory Factors; Final rept. 15 Jul 2005-14 Jul 2006 [R] . Yim, J. H. 2006

机译：乳腺癌细胞的转录激活子重编程基因治疗（TaRGET）与腺病毒载体的干扰素调节因子;最终的评论。 2005年7月15日至2006年7月14日

Successful expression of human factor IX following repeat administration of an adenoviral vector in mice

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