Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

Qing Wang; Terryl Stacy; Michael Binder

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

机译：Cbfa2基因的破坏会导致中枢神经系统坏死和出血，并阻止确定的造血功能

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The CBFA2 (AML1) gene encodes a DNA- binding subunit of the heterodimeric core-binding factor. The CBFA2 gene is disrupted by the (8;21), (3;21), and (12;21) chromosomal translocations associated with leukemias and myelodysplasias in humans. Mice lacking a CBF2 protein capable of binding DNA die between embryonic days 11.5 and 12.5 due to hemorrhaging in the central nervous system (CNS), at the nerve/CNS interfaces of cranial and spinal nerves, and in somitic/intersomitic regions along the pre- sumptive spinal cord.

机译：CBFA2（AML1）基因编码异二聚体核心结合因子的DNA结合亚基。 CBFA2基因被与人类白血病和骨髓增生异常有关的（8; 21），（3; 21）和（12; 21）染色体易位破坏。缺乏能够结合DNA的CBF2蛋白的小鼠会在胚胎第11.5至12.5天之间死于中枢神经系统（CNS），颅神经和脊神经的神经/ CNS界面以及前体的体细胞/间质性区域的出血。脊髓。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3444-3449|共6页
作者
Qing Wang; Terryl Stacy; Michael Binder;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. [O] . Q Wang, T Stacy, M Binder, 1996

机译：Cbfa2基因的破坏会导致中枢神经系统坏死和出血并阻止确定的造血功能。
7. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. [O] . Wang, Q, Stacy, T, Binder, M, 1996

机译：Cbfa2基因的破坏会导致中枢神经系统坏死和出血，并阻止确定的造血功能。

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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