Design and synthesis of ribonucleic guanidine: A polycationic analog of RNA

Robert O. Dempcy; Jia Luo; Thomas C. Bruice

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Design and synthesis of ribonucleic guanidine: A polycationic analog of RNA

机译：RNA的聚阳离子类似物核糖核酸胍的设计与合成

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Replacement of the phosphodiester linkages of the polyanion RNA with guanidinium linkers (represented by g) provides the polycation ribonucleic guanidine (RNG). An anticipated structure for the triple-helical hybrid [r(Up)_9U.(Ag)_9A.(Up)_9U] is presented. A basic strategy for the synthesis of RNG oligomers is described. Synthetic pro- cedures are provided for tetrameric adenosyl RNG [r(Ag)_3A].

机译：聚阴离子RNA的磷酸二酯键与胍鎓连接基（由g表示）的取代提供了聚阳离子核糖核酸胍（RNG）。提出了三螺旋混合体[r（Up）_9U。（Ag）_9A。（Up）_9U]的预期结构。描述了合成RNG低聚物的基本策略。提供了四聚腺苷RNG [r（Ag）_3A]的合成程序。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4326-4330|共5页
作者
Robert O. Dempcy; Jia Luo; Thomas C. Bruice;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Synthesis of ribonucleic guanidine: replacement of the negative phosphodiester linkages of RNA with positive guanidinium linkages [J] . Kojima N., Szabo IE., Bruice TC. Tetrahedron . 2002,第5期

机译：核糖核酸胍的合成：用正胍盐键代替RNA的负磷酸二酯键
2. Replacement of the Phosphorodiester Linkages of RNA with Guanidinium Linkages: The Solid-Phase Synthesis of Ribonucleic Guanidine [J] . Naoshi Kojima, Thomas C. Bruice Organic letters . 2000,第1期

机译：RNA的磷酸二酯键与胍键的替代：核糖胍的固相合成。
3. Studies on transfer ribonucleic acids and related compounds. XXXII. Synthesis of ribonucleotides corresponding to residues 1-5 and 6-10 of tRNAfMet from E.coli and their base conversion analogs [J] . E. Ohtsuka, M. Ikehara, T. Tanaka Nucleic acids research . 1979,第5期

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5. Design and synthesis of amide-linked ribonucleic acids for potential application in RNA interference. [D] . Tanui, Paul Kiptoo. 2013

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6. Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA. [O] . R O Dempcy, J Luo, T C Bruice 1996

机译：核糖核酸胍的设计和合成：RNA的聚阳离子类似物。
7. Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA. [O] . Dempcy, R O, Luo, J, Bruice, T C 1996

机译：核糖核酸胍的设计和合成：RNA的聚阳离子类似物。
8. Synthesis and Biological Evaluation of Brain-Specific Anti-RNA (Ribonucleic Acid) Viral Agents [R] . Brewster, M. E. 1989

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Design and synthesis of ribonucleic guanidine: A polycationic analog of RNA

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