Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy

Martha A. Alexander-Miller; Graham R. Leggatt; Jay A. Berzofsky

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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy

机译：高或低细胞毒性T淋巴细胞的选择性扩增以及过继免疫疗法的功效

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The conventional approach to cytotoxic T- lymphocyte (CTL) induction uses maximal antigen concen- tration with the intent of eliciting more CTL. However, the efficacy of this approach has not been systematically explored with regard to the quality of the CTLs elicited or their in vivo functionality. Here, we show that a diametrically opposite approach elicits CTLs that are much more effective at clearing virus. CTLs specific for a defined peptide epitope were selec- tively expanded with various concentrations of peptide antigen.

机译：诱导细胞毒性T淋巴细胞（CTL）的常规方法使用最大的抗原浓度，以引发更多的CTL。然而，关于所产生的CTL的质量或其体内功能性，尚未系统地探索这种方法的功效。在这里，我们显示出截然相反的方法会引发清除病毒更有效的CTL。对特定肽表位特异的CTLs通过各种浓度的肽抗原选择性扩增。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4102-4107|共6页
作者
Martha A. Alexander-Miller; Graham R. Leggatt; Jay A. Berzofsky;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. [J] . D L Jicha, J J Mulé, S A Rosenberg The Journal of Experomental Medicine . 1991,第6期

机译：白介素7产生抗鼠肉瘤的抗肿瘤细胞毒性T淋巴细胞，在细胞过继免疫疗法中具有功效。
2. Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy. [J] . Sili U, Huls MH, Davis AR, Journal of immunotherapy . 2003,第3期

机译：使用淋巴母细胞细胞系进行过继免疫治疗，以树突状细胞为主的多克隆人细胞毒性T淋巴细胞系的大规模扩增。
3. Programmed Death-Ligand 1 on Antigen-presenting Cells Facilitates the Induction of Antigen-specific Cytotoxic T Lymphocytes: Application to Adoptive T-Cell Immunotherapy [J] . Goto Tatsunori, Nishida Tetsuya, Takagi Erina, Journal of immunotherapy . 2016,第8期

机译：抗原递呈细胞上的程序性死亡配体1有助于诱导抗原特异性细胞毒性T淋巴细胞：在过继T细胞免疫疗法中的应用
4. Injectable chitosan thermogels adapted for cytotoxic T lymphocytes immunotherapy [C] . Caroline Ceccaldi, Anne Monette, Elias Assaad, World biomaterials congress . 2016

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5. Polymers and Polymer-Conjugates for Cancer Immunotherapy: Foreign Cytotoxic T Lymphocyte Epitope Delivery, Cytotoxic T Lymphocyte Activation, and NK92 Cell Surface Engineering [D] . Lang, Shuyao. 2021

机译：癌症免疫疗法聚合物和聚合物 - 缀合物：外国细胞毒性T淋巴细胞表位递送，细胞毒性T淋巴细胞活化，NK92细胞表面工程
6. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. [O] . M A Alexander-Miller, G R Leggatt, J A Berzofsky 1996

机译：高或低毒性细胞毒性T淋巴细胞的选择性扩增以及过继免疫疗法的功效。
7. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. [O] . Alexander-Miller, M A, Leggatt, G R, Berzofsky, J A 1996

机译：高或低细胞毒性的T淋巴细胞的选择性扩增以及过继免疫疗法的功效。
8. Induction of Cytotoxic T Lymphocytes for Immunotherapy of Breast Cancer [R] . Minev, B. R. 2003

机译：诱导细胞毒性T淋巴细胞免疫治疗乳腺癌

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy

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