Neurocytopathic effects of β-amyloid-stimulated monocytes: A potential mechanism for central nervous system damage in Alzheimer disease

Jill A. London; Diane Biegel; Joel S. Pachter

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Neurocytopathic effects of β-amyloid-stimulated monocytes: A potential mechanism for central nervous system damage in Alzheimer disease

机译：β淀粉样蛋白刺激的单核细胞的神经细胞病变作用：阿尔茨海默病中枢神经系统损伤的潜在机制

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Growing evidence indicates that cells of the mononuclear phagocyte lineage, which includes peripheral blood monocytes (PBM) and tissue macrophages, participate in a variety of neurodestructive events and may play a pivotal role in neurodegenerative conditions such as Alzheimer dis- ease. The present study sought to determine whether exposure of PBM to β-amyloid peptide (Aβ), the major protein of the amyloid fibrils that accumulate in the brain in Alzheimer disease, could induce cytopathic activity in these cells upon their subsequent incubation with neural tissue.

机译：越来越多的证据表明，单核吞噬细胞谱系的细胞（包括外周血单核细胞（PBM）和组织巨噬细胞）参与各种神经破坏性事件，并且可能在神经退行性疾病（如阿尔茨海默氏病）中发挥关键作用。本研究试图确定PBM暴露于β-淀粉样肽（Aβ）是阿尔茨海默氏病在大脑中积累的淀粉样蛋白原纤维的主要蛋白，在随后与神经组织孵育后是否可以诱导这些细胞的细胞病变活性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4147-4152|共6页
作者
Jill A. London; Diane Biegel; Joel S. Pachter;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Neurocytopathic effects of β-amyloid-stimulated monocytes: A potential mechanism for central nervous system damage in Alzheimer disease

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