STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

Masashi Minami; Masahiro Inoue; Shi Wei

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STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

机译：STAT3激活是gp130介导的髓样细胞系终末分化和生长停滞的关键步骤

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Myeloid leukemia M1 cells can be induced for growth arrest and terminal differentiation into macro- phages in response to interleukin 6 (IL-6) or leukemia inhib- itory factor (LIF). Recently, a large number of cytokines and growth factors have been shown to activate the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. In the case of IL-6 and LIF, which share a signal transducing receptor gp130, STAT3 is specif- ically tyrosine-phosphorylated and activated by stimulation with each cytokine in various cell types.

机译：可以响应白介素6（IL-6）或白血病抑制因子（LIF）诱导骨髓性白血病M1细胞生长停滞并最终分化为巨噬细胞。最近，已显示大量的细胞因子和生长因子可激活Janus激酶（JAK）信号转导子和转录激活子（STAT）信号转导通路。对于具有信号转导受体gp130的IL-6和LIF，STAT3被酪氨酸磷酸化并通过各种细胞因子对每种细胞因子的刺激而被激活。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.3963-3966|共4页
作者
Masashi Minami; Masahiro Inoue; Shi Wei;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：Batf促进小鼠骨髓白血病细胞的生长停滞和终末分化。
2. PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes. [J] . Roth AD, Leisewitz AV, Jung JE, Journal of Neuroscience Research . 2003,第4期

机译：PPARγ激活剂诱导B12少突胶质细胞样细胞的生长停滞和过程扩展以及培养的少突胶质细胞的终末分化。
3. Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. [J] . Cheng YC, Lin H, Huang MJ, Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2007,第10期

机译：c-Myc的下调对于丙戊酸诱导的急性髓性白血病的生长停滞和髓样分化至关重要。
4. Hyperactivation of gp130-mediated STAT3 signaling induces a rheumatoid arthritis-like disease that is dependent on MHC class II restricted CD4+ T cells [C] . Masaaki Murakami, Shin-ichiro Sawa, Daisuke Kamimura, Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：GP130介导的STAT3信号传导的多动激活诱导类风湿性关节炎样疾病，其依赖于MHC II类限制的CD4 + T细胞
5. Potential roles for transforming growth factor beta during terminal differentiation of ocular lens cells. [D] . Richiert, Dawn Marie. 1996

机译：眼晶状体细胞终末分化过程中转化生长因子β的潜在作用。
6. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. [O] . M Minami, M Inoue, S Wei, 1996

机译：STAT3激活是gp130介导的骨髓细胞系终末分化和生长停滞的关键步骤。
7. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. [O] . Minami, M, Inoue, M, Wei, S, 1996

机译：STAT3激活是gp130介导的骨髓细胞系终末分化和生长停滞的关键步骤。

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

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