Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity

Samir N. Khleif; James DeGregori; Carole L. Yee

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Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关

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Alterations of various components of the cell cycle regulatory machinery that controls the progression of cells from a quiescent to a growing state contribute to the develop- ment of many human cancers. Such alterations include the deregulated expression of G_1 cyclins, the loss of function of activities such as those of protein p16~INK4a that control G_1 cyclin-dependent kinase activity, and the loss of function of the retinoblastoma protein (RB), which is normally regulated by the G_1 cyclin-dependent kinases.

机译：控制细胞从静止状态到生长状态的细胞周期调节机制的各个组成部分的改变，有助于许多人类癌症的发展。这些改变包括G_1细胞周期蛋白的表达失调，诸如控制p_1细胞周期蛋白依赖性激酶活性的蛋白p16〜INK4a的功能丧失以及正常情况下调控的成视网膜细胞瘤蛋白（RB）的功能丧失。 G_1细胞周期蛋白依赖性激酶的作用

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4350-4354|共5页
作者
Samir N. Khleif; James DeGregori; Carole L. Yee;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1 [J] . Genichi Watanabe, Chris Albanese, Richard J. Lee, Molecular and Cellular Biology . 1998,第6期

机译：细胞周期蛋白D1激酶活性的抑制与通过E2F和Sp1的E2F介导的细胞周期蛋白D1启动子活性的抑制有关
2. c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points [J] . Maria K. Mateyak, Alvaro J. Obaya, John M. Sedivy Molecular and Cellular Biology . 1999,第7期

机译：c-Myc调节细胞周期蛋白D-Cdk4和-Cdk6的活性，但影响多个独立点的细胞周期进程。
3. Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells. [J] . Liu F Cell cycle . 2011,第2期

机译：细胞周期蛋白D-CDK4和细胞周期蛋白E-CDK2对Smad3活性的抑制作用。
4. The Prokaryotic Expression of Cyclin-Dependent Kinase 2, and the Establish of Its Inhibitor Screening System [C] . Yuan Yuan, Meile Gao, Huan Liu, International conference on applied biotechnology . 2018

机译：细胞周期蛋白依赖性激酶2的原核表达及其抑制剂筛选系统的建立
5. Cell cycle inhibition as a mode of abnormal development: The role of cell cycle checkpoint proteins and cyclin-dependent kinase inhibitors in neurodevelopmental toxicant defense. [D] . Gribble, Elizabeth J. 2005

机译：细胞周期抑制是异常发育的一种方式：细胞周期检查点蛋白和细胞周期蛋白依赖性激酶抑制剂在神经发育毒物防御中的作用。
6. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. [O] . S N Khleif, J DeGregori, C L Yee, 1996

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关。
7. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. [O] . Khleif, S N, DeGregori, J, Yee, C L, 1996

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关。

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity

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