Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells.

Liu F

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Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells.

机译：细胞周期蛋白D-CDK4和细胞周期蛋白E-CDK2对Smad3活性的抑制作用。

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Breast cancer is one of the most common cancers among women worldwide. Cyclin D1 and cyclin E are frequently overexpressed in breast cancers. Cyclin D1 is overexpressed in ~45% of breast cancers, and cyclin E is overexpressed in -30% of breast cancers.1 Cyclin D or cyclin E overexpression is often found in aggressive breast cancers. Several studies have shown that overexpression of cyclin E or amplification of the cyclin D1 gene is associated with a poor outcome.

机译：乳腺癌是全世界女性中最常见的癌症之一。细胞周期蛋白D1和细胞周期蛋白E在乳腺癌中经常过表达。细胞周期蛋白D1在约45％的乳腺癌中过表达，而细胞周期蛋白E在-30％的乳腺癌中过表达。1在侵袭性乳腺癌中经常发现细胞周期蛋白D或细胞周期蛋白E过表达。几项研究表明，细胞周期蛋白E的过表达或细胞周期蛋白D1基因的扩增与不良预后相关。

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《Cell cycle》 |2011年第2期|共1页
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Liu F;
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正文语种 eng
中图分类细胞生物学;
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1. Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells. [J] . Liu F Cell cycle . 2011,第2期

机译：细胞周期蛋白D-CDK4和细胞周期蛋白E-CDK2对Smad3活性的抑制作用。
2. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity [J] . Samir N. Khleif, James DeGregori, Carole L. Yee Proceedings of the National Academy of Sciences of the United States of America . 1996,第9期

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关
3. Bisphenol S promotes the cell cycle progression and cell proliferation through ER alpha-cyclin D-CDK4/6-pRb pathway in MCF-7 breast cancer cells [J] . Lin Zhenxian, Zhang Xiaona, Zhao Fei, Toxicology and Applied Pharmacology . 2019,第期

机译：通过MCF-7乳腺癌细胞中的ERα-Cyclin D-CDK4 / 6-PRB途径促进细胞周期进展和细胞增殖促进细胞周期进展和细胞增殖
4. Antitumor protein (AP) from a mushroom induced apoptosis to transformed human keratinocyte by controlling the status of pRb, c-MYC, cyclin E-cdk2, and p21~(WAF1) in the G1/S transition [C] . Yukio Kawamura, Mariko Manabe, Kazumi Kitta International Conference on Food Factors . 2000

机译：来自蘑菇的抗肿瘤蛋白（AP）通过控制G1 / S转变中的PRB，C-MYC，Cyclin E-CDK2和P21〜（WAF1）的状态，通过控制PRB，C-MYC，Cyclin E-CDK2和P21〜（WAF1）的状态转化人角蛋白细胞
5. Over-expression of cell cycle kinases, cyclin D-Cdk4, cyclin E-Cdk2, and Aurora A kinase in estrogen-induced pre-neoplastic mammary lesions and tumors in the female ACI rat. [D] . Weroha, Saravut John. 2006

机译：细胞周期激酶，细胞周期蛋白D-Cdk4，细胞周期蛋白E-Cdk2和Aurora A激酶在雌激素诱发的雌性ACI大鼠的乳腺肿瘤前肿瘤病变和肿瘤中的过度表达。
6. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. [O] . S N Khleif, J DeGregori, C L Yee, 1996

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关。
7. Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. [O] . Khleif, S N, DeGregori, J, Yee, C L, 1996

机译：细胞周期蛋白D-CDK4 / CDK6活性的抑制与E2F介导的细胞周期蛋白激酶抑制剂活性的诱导有关。

Inhibition of Smad3 activity by cyclin D-CDK4 and cyclin E-CDK2 in breast cancer cells.

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