Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

Shuichan Xu; David J. Robbins; Lori B. Christerson

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Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

机译：大鼠MEK激酶1 cDNA的克隆揭示了具有大调控域的内源性膜相关195-kDa蛋白

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The coding sequence of rat MEK kinase 1 (MEKK1) has been determined from multiple, independent cDNA clones. The cDNA is full-length based on the presence of stop codons in all three reading frames of the 5' untrans- lated region. Probes from the 5' and the 3' coding sequences both hybridize to a 7-kb mRNA. The open reading frame is 4.5 kb and predicts a protein with molecular mass of 161,225 Da, which is twice the size of the previously published MEKK1 sequence and reveals 801 amino acids of novel coding sequence.

机译：已经从多个独立的cDNA克隆中确定了大鼠MEK激酶1（MEKK1）的编码序列。基于5'非翻译区的所有三个阅读框中存在终止密码子，cDNA为全长。来自5'和3'编码序列的探针均与7-kb mRNA杂交。开放阅读框为4.5 kb，预测分子量为161,225 Da的蛋白质，是先前发表的MEKK1序列大小的两倍，并揭示了801个氨基酸的新编码序列。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第11期|p.5291-5295|共5页
作者
Shuichan Xu; David J. Robbins; Lori B. Christerson;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Cloning and characterization of cDNAs encoding chicken mitogen-activated protein kinase kinase type 2, MEK2: downregulation of MEK2 in response to inhibition of mitochondrial DNA expression [J] . Wang H, Meury L, Morais R Biochemistry . 1997,第49期

机译：编码2型鸡有丝分裂原激活的蛋白激酶激酶MEK2的cDNA的克隆和鉴定：响应线粒体DNA表达的抑制，MEK2下调
2. Identification of cDNA clones encoding valosin-containing protein and other plant plasma membrane-associated proteins by a general immunoscreening strategy. [J] . Shi J, Dixon RA, Gonzales RA, Proceedings of the National Academy of Sciences of the United States of America . 1995,第10期

机译：通过常规免疫筛选策略鉴定编码含缬沙蛋白的蛋白和其他植物质膜相关蛋白的cDNA克隆。
3. cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family [J] . DeMartino George N., Fujiwara Tsutomua, Slaughter Clive A., FEBS Letters . 1996,第2a3期

机译：p42的cDNA克隆，p42是两个蛋白酶体调节蛋白的共享亚基，揭示了AAA蛋白家族的一个新成员
4. Carboxyl Group Protein Footprinting for Mapping the Dimerization Interface and Phosphorylation-induced Conformational Changes of a Membrane-associated Protein Kinase [C] . Hao Zhang, Wei Shen, Ilan Vidavsky, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：羧基蛋白蛋白质覆盖膜相关蛋白激酶的二聚化界面和磷酸化诱导的构象变化
5. Purification, cDNA cloning, and biological significance of a beta-1,3-glucan recognition protein and its amino- and carboxyl-terminal domains from the Indianmeal moth, Plodia interpunctella. [D] . Fabrick, Jeffrey Alan. 2003

机译：来自印度粉蛾Plodia interpunctella的β-1,3-葡聚糖识别蛋白及其氨基和羧基末端结构域的纯化，cDNA克隆及其生物学意义。
6. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. [O] . S Xu, D J Robbins, L B Christerson, 1996

机译：大鼠MEK激酶1 cDNA的克隆揭示了具有大调控域的内源性膜相关195-kDa蛋白。
7. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. [O] . Xu, S, Robbins, D J, Christerson, L B, 1996

机译：大鼠MEK激酶1 cDNA的克隆揭示了具有大调控域的内源性膜相关195-kDa蛋白。
8. Isolation and Sequencing of a cDNA Clone Encoding Lysosomal Membrane Glycoprotein mLAMP-1: Sequence Similarity to Proteins Bearing Onco-Differentiation Antigens [R] . Chenn, J. W., Cha, Y., Yukselt, K. U., 1988

机译：溶酶体膜糖蛋白mLamp-1的cDNa克隆的分离和测序：与携带分化抗原的蛋白质的序列相似性

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

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