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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms
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Ancestral major histocompatibility complex DRB genes beget conserved patterns of localized polymorphisms

机译:祖先主要组织相容性复杂的DRB基因产生保守的局部多态性模式

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摘要

This precisely localized deletion pro- vides direct evidence implicating segmental exchange of MHC- encoded DRB gene fragments as one of the evolutionary mechanisms both generating and maintaining MHC diversity. Intergenic exchange at this site may be fundamental to the diversification of immune protection in populations by per- mitting alteration in the specificity of the MHC that deter- mines the repertoire of antigens bound.
机译:这种精确定位的缺失提供了直接的证据,暗示了MHC编码的DRB基因片段的节段交换是产生和维持MHC多样性的进化机制之一。该位点之间的基因间交换可能通过阻止MHC的特异性改变(决定了结合抗原的组成)而成为人群免疫保护多样化的基础。

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