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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping
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Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping

机译:大鼠细胞色素P450 2C24基因转录本的环状RNA:与外显子跳跃相关

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摘要

The cytochrome P450 2C24 gene is charac- terized by the capability to generate, in rat kidney, a transcript containing exons 2 and 4 spliced at correct sites but having the donor site of exon 4 directly joined to the acceptor site of exon 2 (exon scrambling). By reverse transcriptase-PCR analysis, it is now shown that the only exons present in the scrambled transcript are exons 2, 3, and 4 and that this molecule lacks a poly(A)~+ tail.
机译:细胞色素P450 2C24基因的特征是能够在大鼠肾脏中生成包含在正确位点剪接的外显子2和4的转录本,但外显子4的供体位点直接连接到外显子2的受体位点(外显子加扰) )。通过逆转录酶-PCR分析,现在表明加扰的转录物中仅存在的外显子是外显子2、3和4,并且该分子没有poly(A)++尾巴。

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