Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs

Tai-Soon Yong; Ellen Li; David Clark

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Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs

机译：溶组织内变形杆菌EhADH2基因对大肠杆菌adhE突变体的补充为鉴定新的抗贫血药物提供了一种方法

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The pathogenic protozoan parasite Entam- oeba histolytica, the cause of amebic dysentery and amebic liver abscess, is an obligate anaerobe, and derives energy from the fermentation of glucose to ethanol with pyruvate and acetyl coenzyme A as intermediates. We have isolated EhADH2, a key enzyme in this pathway, that is a NAD~+ - and Fe~2+ -dependent bifunctional enzyme with acetaldehyde dehydrogenase and alcohol dehydrogenase activities.

机译：阿米巴痢疾和阿米巴肝脓肿的病原虫原虫寄生虫阿米巴肠溶菌，是专性厌氧菌，由丙酮酸和丙酮酸辅酶A为中间体的葡萄糖发酵为乙醇而得能量。我们已经分离出EhADH2，这是该途径中的关键酶，它是具有乙醛脱氢酶和乙醇脱氢酶活性的NAD〜+和Fe〜2 +依赖性双功能酶。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6464-6469|共6页
作者
Tai-Soon Yong; Ellen Li; David Clark;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Structural analysis of the acetaldehyde dehydrogenase activity of Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2), a member of the ADHE enzyme family. [J] . Chen M, Li E, Stanley SL Jr Molecular and Biochemical Parasitology . 2004,第2期

机译：变形虫Entamoeba histolytica醇脱氢酶2（EhADH2）（属于ADHE酶家族的成员）的乙醛脱氢酶活性的结构分析。
2. Bioinformatics structural and phylogenetic characterization of Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) [J] . Katie M. Lowerre, Avelina Espinosa, Guillermo Paz-y-Mi?o-C, BIOS . 2019,第1期

机译：Entamoeba组织醇脱氢酶2的生物信息学结构和系统发育表征（EHADH2）
3. Entamoeba histolytica: effect on virulence, growth and gene expression in response to monoxenic culture with Escherichia coli 055. [J] . Mendoza-Macias C. L., Barrios-Ceballos M. P., Cardenas de la Pena L. P., Experimental parasitology . 2009,第2期

机译：组织溶Entamoeba ：响应大肠杆菌 055的单抗培养对毒力，生长和基因表达的影响。
4. Identification of Significant Acylation Pattern Changes in Lipid A species from Escherichia coli lpxL-mutants grown at high temperatures. [C] . Birgit Schilling, Michael A. Apicella, Bradford W. Gibson ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：高温生长的大肠杆菌LPXL-突变体的脂质脂质的显着酰化模式变化。
5. Investigating Rad51 and Dmc1 in Entamoeba histolytica: Homologous Recombinases with Drug Target Potential [D] . Ham, Rachel Evelyn. 2020

机译：在entamoEBA组织溶解中调查Rad51和DMC1：具有药物目标电位的同源重组酶
6. Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs. [O] . T S Yong, E Li, D Clark, 1996

机译：溶组织内变形杆菌EhADH2基因对大肠杆菌adhE突变体的补充为鉴定新的抗贫血药物提供了一种方法。
7. Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs. [O] . Yong, T S, Li, E, Clark, D, 1996

机译：溶组织内变形杆菌EhADH2基因对大肠杆菌adhE突变体的补充为鉴定新的抗贫血药物提供了一种方法。
8. Determination of a Unique Epitope Binding Site for a Complement-Lysis-EnhancingMonoclonal Antibody, 3D12, on the Galactose Adherence Lectin of Entamoeba histolytica, Using BIAcore [R] . Wood, S. J., Petri, W. 1992

机译：使用BIacore测定溶组织内阿米巴半乳糖粘附凝集素补体 - 裂解增强单克隆抗体3D12的独特表位结合位点

Complementation of an Escherichia coli adhE mutant by the Entamoeba histolytica EhADH2 gene provides a method for the identification of new antiamebic drugs

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