Radioimmunotherapy with a ~64Cu-labeled monoclonal antibody: A comparison with ~67Cu

Judith M. Connett; Carolyn J. Anderson; Li-Wu Guo

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Radioimmunotherapy with a ~64Cu-labeled monoclonal antibody: A comparison with ~67Cu

机译：用〜64Cu标记的单克隆抗体进行放射免疫治疗：与〜67Cu的比较

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~67Cu (t_1/2 = 62 h) has demonstrated potential as a radionuclide for radioimmunotherapy, but limited avail- ability severely restricts its widespread use. ~64Cu (t_1/2 = 12.8 h) has been shown to have comparable effectiveness in vitro and in vivo. The present study was undertaken to examine the therapeutic potential of ~64Cu- and ~67Cu-bromoacetamidoben- zyl-1,4,8,11-tetraazacyclotetradecane-N,N',N",N'''-tetra- acetic acid (BAT)-2-iminothiolane (2IT)-1A3 (1A3 is a mouse anti-human colorectal cancer mAb) for treatment of GW39 human colon carcinoma carried in hamster thighs.

机译：〜67Cu（t_1 / 2 = 62 h）已显示出作为放射免疫疗法的放射性核素的潜力，但有限的可用性严重限制了其广泛使用。已显示〜64Cu（t_1 / 2 = 12.8 h）在体外和体内具有相当的效力。本研究旨在检查〜64Cu-和〜67Cu-溴乙酰氨基苯甲酰基-1,4,8,11-四氮杂环十四烷-N，N'，N“，N'''-四乙酸的治疗潜力（ BAT）-2-亚氨基硫杂环戊烷（2IT）-1A3（1A3是小鼠抗人结肠直肠癌单抗），用于治疗仓鼠大腿中携带的GW39人结肠癌。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6814-6818|共5页
作者
Judith M. Connett; Carolyn J. Anderson; Li-Wu Guo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Radioimmunotherapy with a 64Cu-labeled monoclonal antibody: a comparison with 67Cu. [O] . J M Connett, C J Anderson, L W Guo, 1996

机译：用64Cu标记的单克隆抗体进行放射免疫疗法：与67Cu的比较。
7. Radioimmunotherapy with a 64Cu-labeled monoclonal antibody: a comparison with 67Cu. [O] . Connett, J M, Anderson, C J, Guo, L W, 1996

机译：用64Cu标记的单克隆抗体进行放射免疫疗法：与67Cu的比较。
8. Targeted Radioimmunotherapy of Prostate Cancer Using Monoclonal Antibodies to the Extracelluar Domain of Prostate-Specific Membrane Antigen. [R] . Vallabhajosula, S. 2000

机译：使用针对前列腺特异性膜抗原细胞外结构域的单克隆抗体对前列腺癌进行靶向放射免疫治疗。

Radioimmunotherapy with a ~64Cu-labeled monoclonal antibody: A comparison with ~67Cu

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