Negative electrostatic surface potential of protein sites specific for anionic ligands

Polly S. Ledvina; Nanhua Yao; Abha Choudhary

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Negative electrostatic surface potential of protein sites specific for anionic ligands

机译：阴离子配体特异的蛋白质位点的负静电表面电势

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Determination of the crystal structure of an "open" unliganded active mutant (T141D) form of the Esch- erichia coli phosphate receptor for active transport has al- lowed calculation of the electrostatic surface potential for it and two other comparably modeled receptor structures (wild type and D137N). A discovery of considerable implication is the intensely negative potential of the phosphate-binding cleft. We report similar findings for a sulfate transport receptor, a DNA-binding protein, and, even more dramatically, redox proteins.

机译：确定用于主动转运的“磷酸”大肠杆菌受体的“开放”非配体活性突变体（T141D）形式的晶体结构，可以计算出其和两个其他模型化的受体结构（野生型）的静电表面电势和D137N）。发现具有重大意义的是磷酸盐结合裂隙的强烈负电位。我们报告了硫酸盐转运受体，DNA结合蛋白，甚至更重要的是氧化还原蛋白的类似发现。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6786-6791|共6页
作者
Polly S. Ledvina; Nanhua Yao; Abha Choudhary;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Electrostatic forces involved in orienting Anabaena ferredoxin during binding to Anabaena ferredoxin:NADP+ reductase: site-specific mutagenesis, transient kinetic measurements, and electrostatic surface potentials. [J] . Hurley JK, Hazzard JT, Martinez Julvez-M, Protein Science: A Publication of the Protein Society . 1999,第8期

机译：在与鱼腥铁蛋白：NADP +还原酶结合过程中，鱼腥铁蛋白的定向过程中涉及的静电力：位点特异性诱变，瞬态动力学测量和静电表面电势。
2. Structure-based prediction of DNA-binding sites on proteins using the empirical preference of electrostatic potential and the shape of molecular surfaces. [J] . Tsuchiya Y, Kinoshita K, Nakamura H Proteins: Structure, Function, and Genetics . 2004,第4期

机译：基于经验的静电势和分子表面形状的蛋白质上DNA结合位点的基于结构的预测。
3. Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin αIIbβ3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery [J] . Alex AITKEN, Deborah FRENCH, Errol WIJELATH, The biochemical journal . 2000,第3期

机译：野生型和变异型整联蛋白αIIbβ3对表达特定Arg-Gly-Asp（RGD）序列基序的蛇毒蛋白的差异识别：RGD配体识别的不同位点表现出负变构的进一步证据
4. Determination of Site-specific Protein-Ligand Binding Affinities using Protein Ligand Interaction by Mass Spectrometry, Titration, and Hydrogen/Deuterium EXchange (PLMSTEX) Strategy [C] . Jagat Adhikari, Don L. Rempel, Michael L. Gross ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：用质谱法测定蛋白质配体，滴定和氢气/氘交换（PLMSTEX）策略的蛋白质配体相互作用测定特异性蛋白质 - 配体结合亲和力
5. Effect of electrostatic interactions during protein ultrafiltration: Effects of ligand chemistry and protein surface charge distribution. [D] . Rohani, Mahsa Mardoukhi. 2011

机译：蛋白质超滤过程中静电相互作用的影响：配体化学和蛋白质表面电荷分布的影响。
6. Negative electrostatic surface potential of protein sites specific for anionic ligands. [O] . P S Ledvina, N Yao, A Choudhary, 1996

机译：阴离子配体特异的蛋白质位点的负静电表面电势。
7. Negative electrostatic surface potential of protein sites specific for anionic ligands. [O] . Ledvina, P S, Yao, N, Choudhary, A, 1996

机译：阴离子配体特异的蛋白质位点的负静电表面电势。

Negative electrostatic surface potential of protein sites specific for anionic ligands

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