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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Clusters of charged residues in protein three-dimensional structures
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Clusters of charged residues in protein three-dimensional structures

机译:蛋白质三维结构中带电残基的簇

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摘要

Statistically significant charge clusters (ba- sic, acidic, or of mixed charge) in tertiary protein structures are identified by new methods from a large representative collection of protein structures. About 10/100 of protein struc- tures show at least one charge cluster, mostly of mixed type involving about equally anionic and cationic residues. Positive charge clusters are very rare. Negative (or histidine-acidic) charge clusters often coordinate calcium, or magnesium or zinc ions [e.g., thermolysin (PDB code: 3tln), mannose- binding protein (2msb), aminopeptidase (1amp)].
机译:通过新方法从大量具有代表性的蛋白质结构集合中识别出三级蛋白质结构中具有统计意义的重要电荷簇(碱性,酸性或混合电荷)。大约10/100的蛋白质结构显示至少一个电荷簇,大多数为混合型,涉及大约相等的阴离子和阳离子残基。正电荷簇非常罕见。负(或组氨酸酸性)电荷簇通常会协调钙,镁或锌离子[例如,嗜热菌蛋白酶(PDB代码:3tln),甘露糖结合蛋白(2msb),氨肽酶(1amp)]。

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