Haemonchus contortus GA1 antigens: Related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection

Douglas P. Jasmer; Lance E. Perryman; Travis C. McGuire

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Haemonchus contortus GA1 antigens: Related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection

机译：捻转血矛线虫GA1抗原：相关的磷脂酶C敏感，顶肠膜蛋白编码为多蛋白并在感染过程中从线虫释放

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It was previously shown that the Haemonchus contortus apical gut surface proteins p46, p52, and p100 induced protective immunity to challenge infections in goats. Here, it is shown that the three proteins are all encoded by a single gene (GA1) and initially expressed in adult parasites as a polyprotein (p100~GA1). p46~GA1 and p52~GA1 are related pro- teins with 47/100 sequence identity, including a cysteine- containing region, which appears to confer secondary struc- ture to these proteins, and a region with sequence similarity to bacterial Tolb proteins.

机译：先前已证明，捻转血矛线虫（Haemonchus contortus）顶肠表面蛋白p46，p52和p100诱导保护性免疫力，以挑战山羊的感染。此处显示，这三种蛋白质均由单个基因（GA1）编码，并最初在成人寄生虫中以多蛋白（p100〜GA1）的形式表达。 p46〜GA1和p52〜GA1是具有47/100序列同一性的相关蛋白，包括一个半胱氨酸含区，该区似乎赋予了这些蛋白质二级结构，以及一个与细菌Tolb蛋白质具有序列相似性的区域。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8642-8647|共6页
作者
Douglas P. Jasmer; Lance E. Perryman; Travis C. McGuire;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A tissue specific approach for analysis of membrane and secreted protein antigens from Haemonchus contortus gut and its application to diverse nematode species. [J] . Rehman A, Jasmer DP Molecular and Biochemical Parasitology . 1998,第1a2期

机译：一种组织特异性方法，用于分析来自变形杆菌（Haemonchus contortus）肠道的膜和分泌蛋白抗原，并将其应用于多种线虫物种。
2. Protection of calves against Haemonchus placei and Haemonchus contortus after immunization with gut membrane proteins from H. contortus [J] . Bassetto C. C., Silva B. F., Newlands G. F. J., Parasite Immunology . 2011,第7期

机译：牛肠弯曲菌肠膜蛋白免疫后对小牛的羊胎盘和捻转杆菌的保护。
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4. A Potent 37 kDa Outer Membrane Protein Antigen to Immunize Fish against Infection with Bacterium Edwardsiella tarda of Diffent Serotypes [C] . Kenji Kawai, Ying Liu, Syun-ichiro Oshima International Symposium on the Efficient Application and Preservation of Marine Biological Resourecs; 20041029-1102; Qingdao(CN) . 2004

机译：强大的37 kDa外膜蛋白抗原可免疫鱼类以抵抗不同血清型的爱德华氏菌细菌感染
5. Haemonchus contortus GA1 antigens: related phospholipase C-sensitive apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection. [O] . D P Jasmer, L E Perryman, T C McGuire 1996

机译：捻转血矛线虫GA1抗原：相关的磷脂酶C敏感顶肠膜蛋白编码为多蛋白在感染过程中从线虫中释放出来。
6. Haemonchus contortus GA1 antigens: related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection. [O] . Jasmer, D P, Perryman, L E, McGuire, T C 1996

机译：捻转血矛线虫GA1抗原：相关的磷脂酶C敏感，顶肠膜蛋白编码为多蛋白，在感染过程中从线虫中释放出来。
7. Isolation and Sequencing of a cDNA Clone Encoding Lysosomal Membrane Glycoprotein mLAMP-1: Sequence Similarity to Proteins Bearing Onco-Differentiation Antigens [R] . Chenn, J. W., Cha, Y., Yukselt, K. U., 1988

机译：溶酶体膜糖蛋白mLamp-1的cDNa克隆的分离和测序：与携带分化抗原的蛋白质的序列相似性

Haemonchus contortus GA1 antigens: Related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection

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