首页> 外国专利> polyprotein immunogenic complex m. hyopneumoniae synthetic gene encoding the immunogenic complex of polyprotein m. hyopneumoniae antigen composition, process of obtaining a polyprotein immunogenic complex m. hyopneumoniae, the use of a composition based on polyproteins immunogenic complex m. hyopneumoniae

polyprotein immunogenic complex m. hyopneumoniae synthetic gene encoding the immunogenic complex of polyprotein m. hyopneumoniae antigen composition, process of obtaining a polyprotein immunogenic complex m. hyopneumoniae, the use of a composition based on polyproteins immunogenic complex m. hyopneumoniae

机译：多蛋白免疫原性复合物猪肺炎链球菌合成基因，编码多蛋白m的免疫原性复合物。猪肺炎链球菌抗原组成，获得多蛋白免疫原性复合物的过程猪肺炎，基于多蛋白免疫原性复合物的组合物m。猪肺炎

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摘要

polyprotein immunogenic complex m. hyopneumoniae synthetic gene encoding the immunogenic complex of polyprotein m. hyopneumoniae antigen composition, to obtain a complex process depoliprotenas immunogenic m. hyopneumoniae, the use of a composition based on polyproteins immunogenic complex m. hyopneumoniae the present invention refers to a polyprotein regions derived immunogenic complex containing antigens p36, p46, hsp, nrdf, p97, P216 and mhp271 m. hyopneumoniae, these regions that are fused with segments of the carrier proteins rrp4, rrp41 and rrp42 p. abyssi, a single complex. additional objects of the present invention provide: (i) the gene encoding the polyprotein complex, said complex being based on exosome p. abyssi which carries copies of vaccine antigens m. hyopneumoniae; (Ii) a composition comprising the polyprotein antigen complex of the invention, optionally one or more adjuvants and / or additives and a pharmaceutically acceptable carrier; (Lil) a process of obtaining said complex polyprotein; and (iv) uses of said complex and said composition in the treatment and prevention of infections caused by M. hyopneumoniae.

机译：多蛋白免疫原性复合物猪肺炎支原体合成基因，编码多蛋白m的免疫原性复合物。猪肺炎链球菌抗原组成，以复杂的过程获得去脂链球菌的免疫原性。猪肺炎，基于多蛋白免疫原性复合物的组合物m。肺炎性肺炎杆菌本发明涉及衍生自多蛋白区域的免疫原性复合物，其包含抗原p36，p46，hsp，nrdf，p97，P216和mhp271m。肺炎链球菌，这些区域与载体蛋白rrp4，rrp41和rrp42 p的片段融合。阿比西，一个单一的复合体。本发明的其他目的提供：（i）编码多蛋白复合物的基因，所述复合物基于外来体p。携带疫苗抗原拷贝的阿比西m。猪肺炎（ii）组合物，其包含本发明的多蛋白抗原复合物，任选地一种或多种佐剂和/或添加剂以及药学上可接受的载体; （Lil）获得所述复合多蛋白的过程; （iv）所述复合物和所述组合物在治疗和预防由猪肺炎支原体引起的感染中的用途。

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公开/公告号BR102014014727A2

专利类型
公开/公告日2016-03-15

原文格式PDF
申请/专利权人 OURO FINO SAÚDE ANIMAL LTDA;
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申请/专利号BR20141014727
发明设计人 CELSO RAUL ROMERO RAMOS;MIRYAN MARROQUIN QUELOPANA;
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申请日2014-06-16
分类号A61K39/116;A61P37/04;C07K14/30;C12N15/62;
国家 BR
入库时间 2022-08-21 14:27:08

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