首页> 外国专利> COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, SYNTHETIC GENE ENCODING THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, IMMUNOGENIC COMPOSITION, METHOD FOR PRODUCING A COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, USE OF A COMPOSITION BASED ON THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE

COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, SYNTHETIC GENE ENCODING THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, IMMUNOGENIC COMPOSITION, METHOD FOR PRODUCING A COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, USE OF A COMPOSITION BASED ON THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE

机译：肺炎支原体免疫原性蛋白的复合物，编码肺炎支原体免疫原性蛋白的复合基因，免疫原性组合物，复杂的生产方法，由肺炎支原体的免疫原性蛋白复合物组成。猪肺炎支原体

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摘要

The present invention relates to a complex of polyproteins containing immunogenic regions derived from the P36, P46, HSP, NrdF, P97, MHP271 e P216 antigens of M. hyopneumoniae, which regions are fused with segments of the Rrp4. Rrp41 and Rrp42 carrier proteins of P. abyssi, forming a single complex. The present invention further provide the following objects: (i) a gene coding the polyprotein complex, which complex is based on the exosome of P. abyssi and carries copies of vaccine antigens of M. hyopneumoniae; (ii) an antigenic composition comprising the polyprotein complex of the invention, optionally one or more auxiliary agents and/or additives and a pharmacologically acceptable excipient; (iii) a method for producing said polyprotein complex; and (iv) uses of said complex and composition in the treatment and prevention of disease caused by M. hyopneumoniae infection.

机译：本发明涉及一种多蛋白复合物，其包含衍生自I M的P36，P46，HSP，NrdF，P97，MHP271和P216抗原的免疫原性区域。猪肺炎，该区域与Rrp4的片段融合在一起。深渊假单胞菌的Rrp41和Rrp42载体蛋白形成单个复合物。本发明进一步提供以下目的：（i）编码多蛋白复合物的基因，该复合物基于 P的外来体。并带有 M疫苗抗原的副本。（ii）一种抗原组合物，其包含本发明的多蛋白复合物，任选地一种或多种辅助剂和/或添加剂以及药理学上可接受的赋形剂; （iii）生产所述多蛋白复合物的方法; （iv）所述复合物和组合物在治疗和预防由M引起的疾病中的用途。猪肺炎感染。 展开▼

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公开/公告号EP3175864A1

专利类型

公开/公告日2017-06-07

原文格式PDF

申请/专利权人 OURO FINO SAÚDE ANIMAL LTDA.;
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申请/专利号EP20150810570

发明设计人 ROMERO RAMOS CELSO RAUL;MARROQUIN QUELOPANA MIRYAM;
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申请日2015-05-08

分类号A61K39/02;A61K39/116;A61P31/04;

国家 EP

入库时间 2022-08-21 14:02:37

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机译：肺炎支原体免疫原性蛋白的复合物，编码肺炎支原体免疫原性蛋白的复合基因，免疫原性组合物，复杂的生产方法，由肺炎支原体的免疫原性蛋白复合物组成。猪肺炎支原体

4. COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. hyopneumoniae, SYNTHETIC GENE ENCODING THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. hyopneumoniae, IMMUNOGENIC COMPOSITION, METHOD FOR PRODUCING A COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. hyopneumoniae, USE OF A COMPOSITION BASED ON A COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. hyopneumoniae [P] . 美国专利： US2017274062A1 . 2017-09-28

机译：猪肺炎支原体免疫原性蛋白质的复合物，编码猪肺炎支原体免疫原性蛋白质的复合基因，免疫原性组合物，猪肺炎支原体肺炎链球菌的免疫原性蛋白复合物的免疫原性复合物的制备方法，猪肺炎支原体

5. COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, SYNTHETIC GENE ENCODING THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, IMMUNOGENIC COMPOSITION, METHOD FOR PRODUCING A COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE, USE OF A COMPOSITION BASED ON THE COMPLEX OF IMMUNOGENIC POLYPROTEINS OF M. HYOPNEUMONIAE [P] . 世界知识产权组织专利： WO2015192196A1 . 2015-12-23

机译：免疫原性蛋白质的复合体。肺炎链球菌，编码 M的免疫原性蛋白质复合物的合成基因。猪肺炎，免疫原性组合物，生产 M的免疫原性复合物的方法。肺炎链球菌，基于 M免疫原性蛋白质复合物的组合物的使用。猪肺炎

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