The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site

Helen R. Mott; John W. Carpenter; Sheng Zhong

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site

【24h】

The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site

机译：Raf-1富含半胱氨酸的结构域的溶液结构：一个新的Ras和磷脂结合位点

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The Raf-1 protein kinase is the best- characterized downstream effector of activated Ras. Interac- tion with Ras leads to Raf-1 activation and results in trans- duction of cell growth and differentiation signals. The details of Raf-1 activation are unclear, but our characterization of a second Ras-binding site in the cysteine-rich domain (CRD) and the involvement of both Ras-binding sites in effective Raf-1-mediated transformation provides insight into the mo- lecular aspects and consequences of Ras-Raf interactions.

机译：Raf-1蛋白激酶是活化Ras最具特征的下游效应子。与Ras的相互作用导致Raf-1活化，并导致细胞生长和分化信号的转导。 Raf-1激活的细节尚不清楚，但我们对富含半胱氨酸域（CRD）中第二个Ras结合位点的表征以及两个Ras结合位点在有效Raf-1介导的转化中的参与提供了深入的了解Ras-Raf相互作用的分子方面和后果。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8312-8317|共6页
作者
Helen R. Mott; John W. Carpenter; Sheng Zhong;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains [J] . van Blitterswijk WJ. The Biochemical Journal . 1998,第Pta2期

机译：假设：神经酰胺通过与富含半胱氨酸的结构域结合而有条件地激活非典型蛋白激酶C，Raf-1和KSR
2. Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains (letter) [J] . van-Blitterswijk WJ The Biochemical Journal . 1998,第Pta2期

机译：假设：神经酰胺通过结合到富含半胱氨酸的结构域（字母）来有条件地激活非典型蛋白激酶C，Raf-1和KSR
3. Hypothesis: ceramide conditionally activates atypical protein kinases C, Raf-1 and KSR through binding to their cysteine-rich domains [J] . Wim J. van BLITTERSWIJK The biochemical journal . 1998,第2期

机译：假设：神经酰胺通过与富含半胱氨酸的结构域结合而有条件地激活非典型蛋白激酶C，Raf-1和KSR
4. SOlution structure of DNA-binding domain of SW11 protein [C] . (missing) International Beijing conference and exhibition on instrumental analysis . 2003

机译：SW11蛋白DNA结合结构域的溶液结构
5. Part I: Structural and functional insight into the type A CBFbeta-SMMHC protein and acute myeloid leukemia (AML). Part II: Solution structure of the HDGF PWWP domain and implications of its function as a DNA binding domain. [D] . Lukasik, Stephen Michael. 2006

机译：第一部分：对A型CBFbeta-SMMHC蛋白和急性髓细胞性白血病（AML）的结构和功能洞察。第二部分：HDGF PWWP域的溶液结构及其作为DNA结合域的功能的含义。
6. The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. [O] . H R Mott, J W Carpenter, S Zhong, 1996

机译：Raf-1富含半胱氨酸的结构域的溶液结构：一个新的ras和磷脂结合位点。
7. The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. [O] . Mott, H R, Carpenter, J W, Zhong, S, 1996

机译：Raf-1富含半胱氨酸的结构域的溶液结构：一个新的ras和磷脂结合位点。

The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site

摘要

著录项

相似文献

相关主题

期刊订阅