Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice

Krzysztof Reiss; Wei Cheng; Andres Ferber

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Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice

机译：心脏中胰岛素样生长因子-1的过表达与转基因小鼠的心肌细胞增殖相关

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Transgenic mice were generated in which the cDNA for the human insulin-like growth factor 1B (IGF-1B) was placed under the control of a rat -myosin heavy chain promoter. In mice heterozygous for the transgene, IGF-1B mRNA was not detectable in the fetal heart at the end of gestation, was present in modest levels at 1 day after birth, and increased progressively with postnatal maturation, reaching a peak at 75 days.

机译：产生了转基因小鼠，其中将人胰岛素样生长因子1B（IGF-1B）的cDNA置于大鼠-肌球蛋白重链启动子的控制之下。在转基因杂合的小鼠中，妊娠末期在胎儿心脏中未检测到IGF-1B mRNA，在出生后1天以中等水平存在，并随着出生后的成熟逐渐增加，在75天达到峰值。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8630-8635|共6页
作者
Krzysztof Reiss; Wei Cheng; Andres Ferber;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1 [J] . Sylwia S?uczanowska-G??bowska, Maria Laszczyńska, Katarzyna Piotrowska, Journal of Ovarian Research . 2012,第4期

机译：胰岛素样生长因子-1（IGF-1）的血浆循环水平低的白尾侏儒小鼠和胰岛素样生长因子-1的血浆循环水平高的牛GH转基因小鼠卵巢的形态
3. Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1 [J] . Piotrowska Katarzyna, Sluczanowska-Glabowska Sylwia, Kucia Magda, Folia histochemica et cytobiologica . 2015,第3期

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4. EVALUATION OF INSULIN-LIKE GROWTH FACTOR-1 AND PARATHYROID HORMONE ON GROWTH CHARACTERISTICS OF MG-63 CELLS [C] . Laura Franklin, Lisa Haynie, Joel Davis, Annual Rocky Mountain Bioengineering Symposium . 2005

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5. Development and phenotypic characterization of transgenic mice with bone-directed overexpression of insulin-like growth factor-I. [D] . Jiang, Jin. 2002

机译：具有骨样胰岛素样生长因子-I骨过度表达的转基因小鼠的发育和表型特征。
6. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. [O] . K Reiss, W Cheng, A Ferber, 1996

机译：心脏中胰岛素样生长因子-1的过表达与转基因小鼠中的心肌细胞增殖有关。
7. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. [O] . Reiss, K, Cheng, W, Ferber, A, 1996

机译：心脏中胰岛素样生长因子-1的过表达与转基因小鼠中的心肌细胞增殖有关。
8. Collagen and Stretch Modulate Autocrine Secretion of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Proteins from Differentiated Skeletal Muscle Cells [R] . Perrone, C. E. , Fenwick-Smith, D. , Vandenburgh, H. H. 1995

机译：胶原蛋白和拉伸调节胰岛素样生长因子-1和胰岛素样生长因子结合蛋白从分化的骨骼肌细胞分泌自分泌

Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice

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