Altered surfactant function and structure in SP-A gene targeted mice

Thomas R. Korfhagen; Michael D. Bruno; Gary F. Ross

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Altered surfactant function and structure in SP-A gene targeted mice

机译：SP-A基因靶向小鼠的表面活性剂功能和结构改变

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The surfactant protein A (SP-A) gene was disrupted by homologous recombination in embryonic stem cells that were used to generate homozygous SP-A-deficient mice. SP-A mRNA and protein were not detectable in the lungs of SP-A(-/-) mice, and perinatal survival of SP-A(-/-) mice was not altered compared with wild-type mice. Lung morphology, surfactant proteins B-D, lung tissue, alveolar phospholipid pool sizes and composition, and lung compliance in SP-A(-/-) mice were unaltered.

机译：表面活性剂蛋白A（SP-A）基因被胚胎干细胞中的同源重组破坏，该干细胞用于生成纯合SP-A缺陷型小鼠。 SP-A（-/-）小鼠的肺中无法检测到SP-A mRNA和蛋白质，与野生型小鼠相比，SP-A（-/-）小鼠的围产期存活率没有改变。在SP-A（-/-）小鼠中肺形态，表面活性剂蛋白B-D，肺组织，肺泡磷脂库大小和组成以及肺顺应性未改变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9594-9599|共6页
作者
Thomas R. Korfhagen; Michael D. Bruno; Gary F. Ross;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Surfactant protein A (SP-A) gene targeted mice [J] . Thomas R. Korfhagen, Ann Marie LeVine, Jeffrey A. Whitsett Biochimica et biophysica acta. Molecular basis of disease: BBA . 1998,第2期

机译：表面活性蛋白A（SP-A）基因靶向小鼠
2. Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films. I. Micro- and nanostructures of functional pulmonary surfactant films and the effect of SP-A [J] . Zuo YY, Keating E, Zhao L, Biophysical Journal . 2008,第9期

机译：功能和功能异常的肺表面活性剂膜的原子力显微镜研究。一，功能性肺表面活性剂膜的微观和纳米结构及SP-A的作用
3. Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes [J] . Endocrinology . 2013,第1期

机译：缺乏表面活性蛋白A（SP-A）和SP-D或TLR2的小鼠表现出延迟分娩和炎性和收缩基因表达降低
4. Multifunctional Peptide Micelle for Monocyte Targeting and Gene Therapy to Reduce Atherosclerosis [C] . Christopher Poon, Manjima Sarkar, Eun Ji Chung Society for Biomaterials annual meeting and exposition . 2017

机译：多功能肽胶束用于单核细胞靶向和基因治疗以减少动脉粥样硬化
5. The immediate-early gene transcription factors NGFI-A and NGFI-B: Characterization of immune and endocrine functions by targeted mutagenesis in mice [D] . Lee, Stephen Luming 1997

机译：立即早期基因转录因子NGFI-A和NGFI-B：小鼠定向诱变对免疫和内分泌功能的表征
6. Altered surfactant function and structure in SP-A gene targeted mice. [O] . T R Korfhagen, M D Bruno, G F Ross, 1996

机译：SP-A基因靶向小鼠的表面活性剂功能和结构改变。
7. Altered surfactant function and structure in SP-A gene targeted mice. [O] . Korfhagen, T R, Bruno, M D, Ross, G F, 1996

机译：SP-A基因靶向小鼠的表面活性剂功能和结构改变。

Altered surfactant function and structure in SP-A gene targeted mice

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