Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene

Suzanne L. Kirby; Donald N. Cook; William Walton

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Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene

机译：截短的促红细胞生成素受体转基因控制的多能造血细胞的增殖

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摘要

The long-term efficacy of gene therapy using bone marrow transplantation requires the engraftment of genetically altered totipotent hematopoietic stem cells (THSCs). Ex vivo expansion of corrected THSCs is one way to increase the efficiency of the procedure. Similarly, selective in vivo expansion of the therapeutic THSCs rather than the endog- enous THSCs could favor the transplant.

机译：使用骨髓移植进行基因治疗的长期疗效需要植入基因改变的全能造血干细胞（THSC）。校正后的THSC的离体扩增是提高手术效率的一种方法。同样，治疗性THSC而不是内源性THSC的选择性体内扩增可能有利于移植。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9402-9407|共6页
作者
Suzanne L. Kirby; Donald N. Cook; William Walton;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Murine hematopoietic stem cells and multipotent progenitors express truncated intracellular form of c-kit receptor. [J] . Zayas J, Spassov DS, Nachtman RG, Stem cells and development . 2008,第2期

机译：小鼠造血干细胞和多能祖细胞表达截短的细胞内c-kit受体形式。
2. A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells. [J] . G D Longmore, P N Pharr, H F Lodish Molecular and Cellular Biology . 1994,第4期

机译：组成型激活的促红细胞生成素受体刺激增殖，并有助于转化多能，定型的非红系和红系祖细胞。
3. Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line [J] . Pierce A., Owen-Lynch PJ., Tavernier J., Journal of Cell Science . 1998,第Pta6期

机译：异位白细胞介素5受体表达促进增殖而不在多能造血细胞系中发育
4. Promoting Non-Hematopoietic Cell Proliferation by Chimeric Receptors [C] . Kento Tanaka, Masahiro Kawahara, Hiroshi Ueda, Annual Meeting of the Japanese Association for Animal Cell Technology . 2009

机译：通过嵌合受体促进非造血细胞增殖
5. Mechanisms of Epo-mediated hematopoietic progenitor cell proliferation and survival: Roles forc-Kit, Jak2, Pim1 kinase and Y343 of the Epo receptor. [D] . Joneja, Bhavana. 1998

机译：Epo介导的造血祖细胞增殖和存活的机制：作用于Epo受体的forc-Kit，Jak2，Pim1激酶和Y343。
6. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. [O] . S L Kirby, D N Cook, W Walton, 1996

机译：截短的促红细胞生成素受体转基因控制的多能造血细胞的增殖。
7. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. [O] . Kirby, S L, Cook, D N, Walton, W, 1996

机译：截短的促红细胞生成素受体转基因控制的多能造血细胞的增殖。
8. Signaling from a Novel Receptor Tyrosine Kinase and the Control of Multipotent Mammary Progenitor Cells [R] . Wilson, C. A. 2006

机译：来自新型受体酪氨酸激酶的信号传导和多能乳腺祖细胞的控制

Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene

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