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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Induction of myelination in the central nervous system by electrical activity
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Induction of myelination in the central nervous system by electrical activity

机译:通过电活动诱导中枢神经系统的髓鞘形成

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摘要

The oligodendrocyte is the myelin-forming cell in the central nervous system. Despite the close interac- tion between axons and oligodendrocytes, there is little evi- dence that neurons influence myelinogenesis. On the con- trary, newly differentiated oligodendrocytes, which mature in culture in the total absence of neurons, synthesize the myelin- specific constituents of oligodendrocytes differentiated in vivo and even form myelin-like figures. Neuronal electrical activity may be required, however, for the appropriate formation of the myelin sheath.
机译:少突胶质细胞是中枢神经系统中形成髓鞘的细胞。尽管轴突和少突胶质细胞之间存在紧密的相互作用,但几乎没有证据表明神经元会影响髓鞘形成。相反,在完全不存在神经元的情况下在培养中成熟的新分化的少突胶质细胞合成了体内分化的少突胶质细胞的髓鞘特异性成分,甚至形成了类似髓磷脂的图形。然而,可能需要神经元电活动以适当形成髓鞘。

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