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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation
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The conserved role of Krox-20 in directing Hox gene expression during vertebrate hindbrain segmentation

机译:Krox-20在脊椎动物后脑分割过程中指导Hox基因表达的保守作用

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摘要

Transient segmentation in the hindbrain is a fundamental morphogenetic phenomenon in the vertebrate embryo, and the restricted expression of subsets of Hox genes in the developing rhombomeric units and their derivatives is linked with regional specification. Here we show that pattern- ing of the vertebrate hindbrain involves the direct up- regulation of the chicken and pufferfish group 2 paralogous genes, Hoxb-2 and Hoxa-2, in rhombomeres 3 and 5 (r3 and r5) by the zinc finger gene Krox-20.
机译:在脊椎动物胚胎中,后脑中的瞬时分割是一种基本的形态发生现象,并且正在发育的菱形单元及其衍生物中Hox基因子集的限制性表达与区域规范有关。在这里,我们显示了脊椎动物后脑的模式涉及锌指基因在菱形3和5(r3和r5)中直接调控鸡和河豚2组旁系基因Hoxb-2和Hoxa-2。 Krox-20。

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