Chromatin structure and gene expression

Gary Felsenfeld; Joan Boyes; Jay Chung

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Chromatin structure and gene expression

机译：染色质结构和基因表达

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It is now well understood that chromatin structure is perturbed in the neighborhood of expressed genes. This is most obvious in the neighborhood of promoters and enhancers, where hypersensitivity to nucleases marks sites that no longer carry canonical nucleosomes, and to which transcription factors bind. To study the relationship between transcription factor binding and the generation of these hypersensitive regions, we mutated individual cis-acting reg- ulatory elements within the enhancer that lies between the chicken β- and ε-globin genes.

机译：现在众所周知，染色质结构在表达的基因附近受到干扰。这在启动子和增强子附近最为明显，那里对核酸酶的超敏反应标志着不再携带经典核小体并与转录因子结合的位点。为了研究转录因子结合与这些超敏区域的产生之间的关系，我们突变了位于鸡β-和ε-珠蛋白基因之间的增强子中的各个顺式作用调节元件。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9384-9388|共5页
作者
Gary Felsenfeld; Joan Boyes; Jay Chung;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo. [J] . Deuring R, Fanti L, Armstrong JA, Molecular cell . 2000,第2期

机译：ISWI染色质重塑蛋白是基因表达和体内高阶染色质结构维持所必需的。
2. Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure [J] . Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Epigenetics & Chromatin . 2017,第1期

机译：α-珠蛋白基因表达的激活与附近非珠蛋白基因的急剧上调以及局部和大规模染色质空间结构的变化有关
3. Expression of GATA-1 in a Non-hematopoietic Cell Line Induces beta-Globin Locus Control Region Chromatin Structure Remodeling and an Erythroid Pattern of Gene Expression. [J] . Layon ME, Ackley CJ, West RJ, Journal of Molecular Biology . 2007,第3期

机译：GATA-1在非造血细胞系中的表达诱导β-球蛋白基因座控制区的染色质结构重塑和基因表达的类胡萝卜素模式。
4. Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes [C] . Silvia Monticelli, K. Mark Ansel, Dong U. Lee, Symposium on Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease . 2005

机译：肥大细胞中基因表达的调节：细胞因子基因的微RNA表达和染色质结构分析
5. Modulating Chromatin Structure and Gene Expression During African Swine Fever Virus Infection : New Strategies for an Efficient Vaccine Rational Design [D] . Frouco, Gon?alo Daniel dos Santos. 2018

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6. Epigenetic Modulation of Chromatin States and Gene Expression by G-Quadruplex Structures [O] . Chiara Reina, Vincenzo Cavalieri 2020

机译：染色质状态的表观遗传调控和基因表达的G四联体结构。
7. Chromatin architecture and transcriptional regulation at the Epidermal Differentiation Complex (EDC) locus. The role of epigenetic factors in modulating chromatin structure and tissue-specific gene expression at the murine EDC locus during epidermal differentiation. [O] . Yarker Joanne Lauren 2014

机译：表皮分化复合体（EDC）位点的染色质结构和转录调控。表观遗传因素在表皮分化过程中在小鼠EDC基因座上调节染色质结构和组织特异性基因表达的作用。

Chromatin structure and gene expression

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