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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Propagation of an attenuated virus by design: Engineering a novel receptor for a noninfectious foot-and-mouth disease virus
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Propagation of an attenuated virus by design: Engineering a novel receptor for a noninfectious foot-and-mouth disease virus

机译:通过设计传播减毒病毒:工程化非传染性口蹄疫病毒的新型受体

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摘要

To gain entry into cells, viruses utilize a variety of different cell-surface molecules. Foot-and-mouth disease virus (FMDV) binds to cell-surface integrin molecules via an arginine-glycine-aspartic acid (RGD) sequence in capsid protein VP1. Binding to this particular cell-surface molecule influences FMDV tropism, and virus/receptor in- teractions appear to be responsible, in part, for selection of antigenic variants.
机译:为了进入细胞,病毒利用了多种不同的细胞表面分子。口蹄疫病毒(FMDV)通过衣壳蛋白VP1中的精氨酸-甘氨酸-天冬氨酸(RGD)序列与细胞表面整联蛋白分子结合。与这种特定的细胞表面分子的结合会影响FMDV的向性,并且病毒/受体相互作用似乎部分负责选择抗原性变体。

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