NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca~2+ concentration by activating voltage-gated K~+ channels

Xiao-Jian Yuan; Mary L. Tod; Lewis J. Rubin

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NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca~2+ concentration by activating voltage-gated K~+ channels

机译：NO通过激活电压门控的K〜+通道使肺动脉平滑肌细胞超极化并降低细胞内Ca〜2 +浓度

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NO causes pulmonary vasodilation in pa- tients with pulmonary hypertension. In pulmonary arterial smooth muscle cells, the activity of voltage-gated K+ (K_V) channels controls resting membrane potential. In turn, mem- brane potential is an important regulator of the intracellular free calcium concentration ([Ca~2+]i) and pulmonary vascular tone. We used patch clamp methods to determine whether the NO-induced pulmonary vasodilation is mediated by activation of K_V channels.

机译：NO会导致肺动脉高压患者的肺血管舒张。在肺动脉平滑肌细胞中，电压门控的K +（K_V）通道的活动控制着静息膜电位。反过来，膜电位是细胞内游离钙浓度（[Ca〜2 +] i）和肺血管张力的重要调节剂。我们使用膜片钳方法来确定NO诱导的肺血管舒张是否由K_V通道的激活介导。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第19期|p.10489-10494|共6页
作者
Xiao-Jian Yuan; Mary L. Tod; Lewis J. Rubin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Relationship of Intracellular Free Ca~(2+) Concentration and Calcium-activated Chloride Channels of Pulmonary Artery Smooth Muscle Cells in Rats under Hypoxic Conditions [J] . YANG Zhao, ZHANG Zhenxiang, XU Yongjian, Journal of Huazhong University of Science and Technology . 2006,第2期

机译：低氧条件下大鼠肺动脉平滑肌细胞内游离Ca〜（2+）浓度与钙激活氯离子通道的关系
2. Intracellular Mg(2+) hyperpolarizes rabbit coronary artery smooth muscle cells by differential modulation of Ca(2+)(i)-dependent ion channels. [J] . Bae M, Kim S, Ko E, Pfluegers Archiv: European Journal of Physiology . 2002,第4期

机译：细胞内Mg（2+）通过Ca（2 +）（i）依赖离子通道的差异调制来超极化兔冠状动脉平滑肌细胞。
3. Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscles cells in nitrofen-induced congenital diaphragmatic hernia in rats. [J] . Sakai M, Unemoto K, Solari V, Pediatric surgery international . 2004,第3期

机译：大鼠硝基芬诱发的先天性diaphragm肌疝中肺动脉平滑肌细胞中电压门控性K +通道的表达降低。
4. Taurine induces the apoptosis in Pulmonary Artery Smooth Muscle Cells [C] . Xiaodan Zhang, Jiejing Sheng, Fenghua Zhao, International conference on environmental biotechnology and materials engineering;EBME 2011 . 2011

机译：牛磺酸诱导肺动脉平滑肌细胞凋亡
5. Modulation of the pharmacology of Ca2+-activated Cl- channels of pulmonary artery smooth muscle cells and the molecular candidate TMEM16A by phosphorylation. [D] . Wiwchar, Michael. 2010

机译：通过磷酸化调节肺动脉平滑肌细胞Ca2 +激活的Cl-通道和分子候选TMEM16A的药理作用。
6. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. [O] . X J Yuan, M L Tod, L J Rubin, 1996

机译：NO通过激活电压门控的K +通道使肺动脉平滑肌细胞超极化并降低细胞内Ca2 +浓度。
7. NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels. [O] . Yuan, X J, Tod, M L, Rubin, L J, 1996

机译：NO通过激活电压门控的K +通道使肺动脉平滑肌细胞超极化并降低细胞内Ca2 +浓度。

NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca~2+ concentration by activating voltage-gated K~+ channels

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