Reactive oxygen species are downstream mediators of p53-dependent apoptosis

Thomas M. Johnson; Zu-Xi Yu; Victor J. Ferrans

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Reactive oxygen species are downstream mediators of p53-dependent apoptosis

机译：活性氧是p53依赖性细胞凋亡的下游介质

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Reactive oxygen species (ROS) have been implicated as potential modulators of apoptosis. Conversely, experiments under hypoxic conditions have suggested that apoptosis could occur in the absence of ROS. We sought to determine whether a central modulator of apoptosis, p53, regulates the levels of intracellular ROS and whether a rise in ROS levels is required for the induction of p53-dependent apoptosis.

机译：活性氧（ROS）被认为是凋亡的潜在调节剂。相反，在低氧条件下的实验表明，在没有ROS的情况下可能发生凋亡。我们试图确定凋亡的中央调节剂p53是否调节细胞内ROS的水平，以及是否需要ROS水平的升高来诱导p53依赖性凋亡。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11848-11852|共5页
作者
Thomas M. Johnson; Zu-Xi Yu; Victor J. Ferrans;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：叶黄素通过由反应性氧物质介导的P53依赖性线粒体信号通路诱导骨髓增生综合征衍生细胞凋亡
2. Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic carcinoma cells carrying a mutant p53 gene. [J] . Kobayashi D, Sasaki M, Watanabe N Pancreas . 2001,第3期

机译：Caspase-3在活性氧下游下游，在热诱导的携带突变p53基因的胰腺癌细胞凋亡中起作用。
3. Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. [J] . Kim YH, Jung EM, Lee TJ, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2008,第6期

机译：罗格列酮通过活性氧介导的死亡受体5的上调和c-FLIP的下调来促进肿瘤坏死因子相关的凋亡诱导配体诱导的凋亡。
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Selenocystine induces mitochondrial-mediated apoptosis in breast carcinoma MCF-7 cells and melanoma A-375 cells with involvement of p53 phosphorylation and reactive oxygen species. [D] . Chen, Tianfeng. 2008

机译：硒代胱氨酸在p53磷酸化和活性氧的参与下，诱导乳腺癌MCF-7细胞和黑色素瘤A-375细胞的线粒体介导的凋亡。
6. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. [O] . T M Johnson, Z X Yu, V J Ferrans, 1996

机译：活性氧是p53依赖性细胞凋亡的下游介质。
7. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. [O] . Johnson, T M, Yu, Z X, Ferrans, V J, 1996

机译：活性氧是p53依赖性细胞凋亡的下游介质。

Reactive oxygen species are downstream mediators of p53-dependent apoptosis

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