Regulation of striatal D_1A dopamine receptor gene transcription by Brn-4

Hitoshi Okazawa; Ichiro Imafuku; Mari T. Minowa

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Regulation of striatal D_1A dopamine receptor gene transcription by Brn-4

机译：Brn-4对纹状体D_1A多巴胺受体基因转录的调控

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Brn-4 is a member of the POU transcription factor family and is expressed in the central nervous system. In this study, we addressed whether Brn-4 regulates expres- sion of the D_1A dopamine receptor gene. We found a functional Brn-4 responsive element in the intron of this gene by means of cotransfection chloramphenical acetyltransferase assays. This region contains two consensus sequences for binding of POU factors. Gel mobility-shift assays using glutathione S-transferase-Brn-4 fusion protein indicated that Brn-4 binds to these sequences.

机译：Brn-4是POU转录因子家族的成员，在中枢神经系统中表达。在这项研究中，我们探讨了Brn-4是否调节D_1A多巴胺受体基因的表达。我们通过共转染氯霉素乙酰转移酶测定法在该基因的内含子中发现了一个功能性的Brn-4响应元件。该区域包含两个用于结合POU因子的共有序列。使用谷胱甘肽S-转移酶-Brn-4融合蛋白的凝胶迁移率迁移分析表明，Brn-4与这些序列结合。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11933-11938|共6页
作者
Hitoshi Okazawa; Ichiro Imafuku; Mari T. Minowa;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Regulation of striatal D_1A dopamine receptor gene transcription by Brn-4

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