Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation

Serguei Popov; Larisa Dubrovsky; May-Ann Lee

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Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation

机译：逆转录酶在CNI-H0294抑制HIV-1核转运中的关键作用

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HIV-1 replication requires the translocation of viral genome into the nucleus of a target cell. We recently reported the synthesis of an arylene bis(methyl ketone) com- pound (CNI-H0294) that inhibits nuclear targeting of the HIV-1 genome and thus HIV-1 replication in monocyte cul- tures. Here we demonstrate that CNI-H0294 inhibits nuclear targeting of HIV-1-derived preintegration complexes by inac- tivating the nuclear localization sequence of the HIV-1 matrix antigen in a reaction that absolutely requires reverse trans- criptase.

机译：HIV-1复制需要将病毒基因组转位到靶细胞的核中。我们最近报道了亚芳基双（甲基酮）化合物（CNI-H0294）的合成，该化合物可抑制HIV-1基因组的核靶向，从而抑制HIV-1在单核细胞培养物中的复制。在这里，我们证明CNI-H0294通过在绝对需要逆转录酶的反应中激活HIV-1基质抗原的核定位序列，从而抑制了HIV-1衍生的预整合复合物的核靶向。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11859-11864|共6页
作者
Serguei Popov; Larisa Dubrovsky; May-Ann Lee;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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5. Mechanisms by which nonnucleoside reverse transcriptase inhibitors block HIV-1 replication alone and in combination with other reverse transcriptase inhibitors [D] . Radzio, Jessica Ann 2010

机译：非核苷类逆转录酶抑制剂单独或与其他逆转录酶抑制剂合用可阻断HIV-1复制的机制
6. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. [O] . S Popov, L Dubrovsky, M A Lee, 1996

机译：逆转录酶在CNI-H0294对HIV-1核易位的抑制机制中的关键作用。
7. Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. [O] . Popov, S, Dubrovsky, L, Lee, M A, 1996

机译：逆转录酶在CNI-H0294对HIV-1核易位的抑制机制中的关键作用。

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation

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