Haemophilus influenzae pili are composite structures assembled via the HifB chaperone

Joseph W. St. Geme III; Jerome S. Pinkner; Graham P. Krasan

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Haemophilus influenzae pili are composite structures assembled via the HifB chaperone

机译：流感嗜血菌菌毛是通过HifB分子伴侣组装的复合结构

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Haemophilus influenzae is a Gram-negative bacterium that represents a common cause of human disease. Disease due to this organism begins with colonization of the upper respiratory mucosa, a process facilitated by adhesive fibers called pili. In the present study, we investigated the structure and assembly of H. influenzae pili. Examination of pili by electron microscopy using quick-freeze, deep-etch and immunogold techniques revealed the presence of two distinct subassemblies, including a flexible two-stranded helical rod comprised of HifA and a short, thin, distal tip structure containing HifD.

机译：流感嗜血杆菌是革兰氏阴性细菌，代表人类疾病的常见原因。由该生物体引起的疾病始于上呼吸道粘膜的定植，这一过程由称为菌毛的粘性纤维促进。在本研究中，我们调查了流感嗜血菌菌毛的结构和组装。通过使用快速冷冻，深蚀刻和免疫金技术的电子显微镜检查菌毛，发现存在两个截然不同的子组件，包括一个由HifA组成的灵活的双链螺旋杆和一个包含HifD的短而细的远端尖端结构。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11913-11918|共6页
作者
Joseph W. St. Geme III; Jerome S. Pinkner; Graham P. Krasan;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae. [J] . J R Gilsdorf, H Y Chang, K W McCrea, Infection and immunity . 1992,第2期

机译：比较b型流感嗜血杆菌的血凝菌毛与不可分型流感嗜血杆菌的相似结构。
2. Purification and characterization of Haemophilus influenzae pili, and their structural and serological relatedness to Escherichia coli P and mannose-sensitive pili. [J] . N G Guerina, S Langermann, G K Schoolnik, The Journal of Experomental Medicine . 1985,第1期

机译：流感嗜血菌菌毛菌毛的纯化和表征，以及它们与大肠杆菌P和甘露糖敏感菌毛的结构和血清学相关性。
3. Structure and Function of Hib Pili from Haemophilus influenzae Type b [J] . Xiang-Qi Mu, Edward H. Egelman, Esther Bullitt Journal of bacteriology . 2002,第17期

机译：b型流感嗜血杆菌Hib菌毛的结构和功能
4. Studies on the Mechanism of Electrochemical Detection of Haemophilus Influenzae at Diamond-Based Electrodes [C] . Marcin Krzysztof Kowalski, Mateusz Brodowski, Karolina Dziqbowska, Meeting of the Electrochemical Society;International Meeting on Chemical Sensors . 2020

机译：金刚石电极电化学检测电化学检测机理研究
5. Crystal structures of GfcC, a group 4 capsule operon protein from Escherichia coli, and YraM, an outer membrane lipoprotein from Haemophilus influenzae. [D] . Sathiyamoorthy, Karthik. 2011

机译：GfcC（一种来自大肠杆菌的第4组胶囊操纵子蛋白）和YraM（一种来自流感嗜血杆菌的外膜脂蛋白）的晶体结构。
6. Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. [O] . J W St Geme, J S Pinkner 3rd, G P Krasan, 1996

机译：流感嗜血菌菌毛是通过HifB分子伴侣组装的复合结构。
7. Haemophilus influenzae pili are composite structures assembled via the HifB chaperone. [O] . St Geme, J W, Pinkner, J S, Krasan, G P, 1996

机译：流感嗜血菌菌毛是通过HifB分子伴侣组装的复合结构。

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Haemophilus influenzae pili are composite structures assembled via the HifB chaperone

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