A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

Shu-wei Yang; Alex B. Burgin Jr.; Beth N. Huizenga

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

机译：可以分离DNA和I型拓扑异构酶之间的末端共价复合物的真核酶

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摘要

The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of circum- stances, the covalent complex is converted to a long-lived or dead-end product that can result in chromosome breakage and cell death. We have discovered and partially purified an enzyme that specifically cleaves the chemical bond that joins the active site tyrosine of topoisomerases to the 3' end of DNA.

机译：拓扑异构酶与DNA的共价连接通常是这些重要酶反应周期中的一个过渡步骤。但是，在多种情况下，共价复合物会转化为长寿或死胡同的产物，这会导致染色体断裂和细胞死亡。我们发现并部分纯化了一种酶，该酶可特异性切割将拓扑异构酶的活性位点酪氨酸连接到DNA的3'末端的化学键。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第21期|p.11534-11539|共6页
作者
Shu-wei Yang; Alex B. Burgin Jr.; Beth N. Huizenga;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Vaccinia virus DNA topoisomerase: a model eukaryotic type IB enzyme [J] . Stewart Shuman Biochimica et biophysica acta. Gene structure and expression . 1998,第1期

机译：牛痘病毒DNA拓扑异构酶：真核IB型模型酶
2. Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity [J] . Kohorst Mira A., Flatten Karen S., Peterson Kevin L., Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：Topoisomerase I-DNA在骨髓恶性肿瘤中的共价复合物：潜在的拓扑异构酶酶I抑制剂敏感性
3. Structural Studies of E. coli Topoisomerase III-DNA Complexes Reveal a Novel Type IA Topoisomerase-DNA Conformational Intermediate. [J] . Changela A, Digate RJ, Mondragon A Journal of Molecular Biology . 2007,第1期

机译：大肠杆菌拓扑异构酶III-DNA复合物的结构研究揭示了一种新型的IA型拓扑异构酶-DNA构象中间体。
4. Three-body fragment ion in Positive and Negative ESI for Location of Non-covalent Binding Sites in DNA/Peptide complexes [C] . Jean-Claude Tabet, Bessem Brahim, Sandra Alves, International Mass Spectrometry Conference . 2014

机译：正面和阴性ESI中的三体片段离子，用于DNA /肽复合物中非共价结合位点的位置
5. MRE11 processes topoisomerase-DNA covalent complexes in vivo. [D] . Hamilton, Nicolle K. 2010

机译：MRE11在体内处理拓扑异构酶-DNA共价复合物。
6. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases. [O] . S W Yang, A B Burgin Jr, B N Huizenga, 1996

机译：可以分离DNA和I型拓扑异构酶之间的末端共价复合物的真核酶。
7. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases. [O] . Yang, S W, Burgin, A B, Huizenga, B N, 1996

机译：可以分离DNA和I型拓扑异构酶之间的末端共价复合物的真核酶。
8. Compositions and Methods for the Detection of DNA Topoisomerase II Complexes with DNA. [R] . Felix, C. A., Baldwin, D. A. 2005

机译：用于检测DNa拓扑异构酶II与DNa的复合物的组合物和方法。

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

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