Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene α0 accumulate in the cytoplasm of infected cells

Kara L. Carter; Bernard Roizman

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Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene α0 accumulate in the cytoplasm of infected cells

机译：选择性剪接的mRNA预计会产生移码蛋白，并且单纯疱疹病毒1调控基因α0的稳定内含子1 RNA积累在受感染细胞的细胞质中

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The infected cell protein no. 0 (ICP0), the product of the 0 gene, and an important herpes simplex virus 1 regulatory protein is encoded by three exons. We report that intron 1 forms a family of four stable nonpolyadenylylated cytoplasmic RNAs sharing a common 5' end but differing in 3' ends. The 5' and 3' ends correspond to the accepted splice donor and four splice acceptor sites within the mapped intron domain. The most distant splice acceptor site yields the mRNA encoding the 775-aa protein known as ICP0.

机译：感染的细胞蛋白编号0（ICP0）是0基因的产物，是重要的单纯疱疹病毒1调节蛋白，由三个外显子编码。我们报告内含子1形成四个稳定的非polyadenylylated胞质RNA共享一个共同的5'端，但在3'端不同的家庭。 5'和3'端对应于映射的内含子域内的可接受的剪接供体和四个剪接受体位点。最远的剪接受体位点产生编码775-aa蛋白的mRNA，称为ICP0。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第22期|p.12535-12540|共6页
作者
Kara L. Carter; Bernard Roizman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Open reading frame P - a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA [J] . Renato Bruni, Bernard Roizman Proceedings of the National Academy of Sciences of the United States of America . 1996,第19期

机译：开放阅读框P-在生产性感染期间被抑制的单纯疱疹病毒基因编码一种蛋白质，该蛋白质与剪接因子结合并减少由剪接的mRNA制成的病毒蛋白质的合成
2. Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs [J] . Audrey Li, Gong-Ping He, Hyo-Sung Ro, Nucleic acids research . 1994,第4期

机译：小鼠核糖体蛋白S24多基因家族的分子表征：独特表达的含内含子基因，具有三个交替剪接的mRNA的细胞特异性表达
3. Effects of interferon on immediate-early mRNA and protein levels in sensory neuronal cells infected with herpes simplex virus type 1 or pseudorabies virus [J] . Van Opdenbosch Nina, De Regge Nick, Van Poucke Mario, Veterinary Microbiology . 2011,第3a4期

机译：干扰素对感染1型单纯疱疹病毒或伪狂犬病病毒的感觉神经元细胞早期早期mRNA和蛋白水平的影响
4. Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes [C] . Richard E. Green, Benjamin P. Lewis, R. Tyler Hillman, International Conference on Intelligent Systems for Molecular biology . 2003

机译：普遍预测的无意义介导的mRNA衰减的人正常和疾病基因的替代剪接转录物
5. Studies on the export of viral mRNA by the herpes simplex virus type 1 regulatory protein ICP27. [D] . Johnson, Lisa A. 2009

机译：单纯疱疹病毒1型调节蛋白ICP27出口病毒mRNA的研究。
6. Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells. [O] . K L Carter, B Roizman 1996

机译：选择性剪接的mRNA预计会产生移码蛋白而单纯疱疹病毒1调节基因alpha 0的稳定内含子1 RNA积累在受感染细胞的细胞质中。
7. Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells. [O] . Carter, K L, Roizman, B 1996

机译：选择性剪接的mRNA预计会产生移码蛋白，而单纯疱疹病毒1调节基因alpha 0的稳定内含子1 RNA会积累在被感染细胞的细胞质中。

Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene α0 accumulate in the cytoplasm of infected cells

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