Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development

Julia R. Kohler; Gerald R. Fink

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Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development

机译：白色念珠菌菌株在有丝分裂原激活的蛋白激酶信号转导成分中的突变是杂合的和纯合的

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The Candida albicans genes, CST20 and HST7, were cloned by their ability to suppress the mating defects of Saccharomyces cerevisiae mutants in the ste20 and ste7 genes, which code for elements of the mating mitogen- activated protein (MAP) kinase pathway. These Candida genes are both structural and functional homologs of the cognate Saccharomyces genes. The pattern of suppression in Saccharomyces is related to their presumptive position in the MAP kinase cascade. Null alleles of these genes were constructed in Candida.

机译：克隆了白色念珠菌基因CST20和HST7，它们具有抑制酿酒酵母突变体ste20和ste7基因中的交配缺陷的能力，这些突变体编码交联的有丝分裂原活化蛋白（MAP）激酶途径的元素。这些假丝酵母基因是同源酿酒酵母基因的结构和功能同源物。酿酒酵母中抑制的模式与其在MAP激酶级联反应中的假定位置有关。这些基因的无效等位基因在假丝酵母中构建。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.13223-13228|共6页
作者
Julia R. Kohler; Gerald R. Fink;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Candida albicans Lacking the Gene Encoding the Regulatory Subunit of Protein Kinase A Displays a Defect in Hyphal Formation and an Altered Localization of the Catalytic Subunit [J] . Alejandro Cassola, Marc Parrot, Susana Silberstein, Eukaryotic cell . 2004,第1期

机译：白色念珠菌缺乏编码蛋白激酶A调节亚基的基因显示菌丝形成缺陷和催化亚基的改变的位置。
2. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans [J] . Ekkehard Leberer, Doreen Harcus, Ian D. Broadbent Proceedings of the National Academy of Sciences of the United States of America . 1996,第23期

机译：通过Ste20p和Ste7p蛋白激酶同源物的信号转导可触发致病真菌白色念珠菌中的菌丝形成
3. Cpp1 phosphatase mediated signaling crosstalk between Hog1 and Cek1 mitogen-activated protein kinases is involved in the phenotypic transition in Candida albicans [J] . Deng Fu-Sheng, Lin Ching-Hsuan Medical mycology: official publication of the International Society for Human and Animal Mycology . 2018,第2期

机译：CPP1磷酸酶介导的肝脏和Ceκ1丝裂剂活化蛋白激酶之间的信号串扰参与念珠菌蛋白蛋白酶的表型转变
4. Activation of Mitogen-activated Protein Kinases and Protein Kinase B/akt Signaling By Oxidative Stress in Vascular Smooth Muscle Cells: involvement in Vascular Pathophysiology [C] . Ashok K. Srivastava, Nihar R. Pandey, Antoine Blanc International Society for Heart Research.Congress . 2004

机译：血管平滑肌细胞氧化应激激活丝裂剂活化蛋白激酶和蛋白激酶B / Akt信号传导：血管病理生理学中的参与
5. Regulation of mitogen-activated protein kinase and phosphoinositide 3-kinase signaling by wild-type and oncogenic Ras. [D] . Young, Amy. 2011

机译：野生型和致癌性Ras对促分裂原活化蛋白激酶和磷酸肌醇3激酶信号传导的调节。
6. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development [O] . Julia R. Köhler, Gerald R. Fink 1996

机译：白色念珠菌菌株杂合子和纯合子在丝裂原激活的蛋白激酶信号转导中的突变组件在菌丝发育中有缺陷
7. Repression of Hyphal Proteinase Expression by the Mitogen-Activated Protein (MAP) Kinase Phosphatase Cpp1p of Candida albicans Is Independent of the MAP Kinase Cek1p [O] . Schröppel, Klaus, Sprößer, Katrin, Whiteway, Malcolm, 2000

机译：白念珠菌的丝裂原激活蛋白（MAP）激酶磷酸酶Cpp1p抑制菌丝蛋白酶表达独立于MAP激酶Cek1p。

Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development

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