Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

Michele Bernasconi; Andrew Remppis; William J. Fredericks

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Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

机译：下调PAX蛋白诱导横纹肌肉瘤细胞凋亡

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The expression of a number of human paired box-containing (PAX) genes has been correlated with various types of tumors. Novel fusion genes encoding chimeric fusion proteins have been found in the pediatric malignant tumor alveolar rhabdomyosarcoma (RMS). They are generated by two chromosomal translocations t(2;13) and t(1;13) juxtapos- ing PAX3 or PAX7, respectively, with a forkhead domain gene FKHR. Here we describe that specific down-regulation of the t(2;13) translocation product in alveolar RMS cells by anti- sense oligonucleotides results in reduced cellular viability.

机译：许多人类配对含盒（PAX）基因的表达已与各种类型的肿瘤相关。在小儿恶性肿瘤肺泡横纹肌肉瘤（RMS）中发现了编码嵌合融合蛋白的新型融合基因。它们是由两个分别与PAX3或PAX7相邻的染色体易位t（2; 13）和t（1; 13）与叉头域基因FKHR产生的。在这里我们描述了反义寡核苷酸对肺泡RMS细胞中t（2; 13）易位产物的特异性下调导致细胞活力降低。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第23期|p.13164-13169|共6页
作者
Michele Bernasconi; Andrew Remppis; William J. Fredericks;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Sphingosine Induces Apoptosis and Down-regulation of MYCN in PAX3-FOXO1-positive Alveolar Rhabdomyosarcoma Cells Irrespective of TP53 Mutation [J] . Ahn Eun Hyun, Lee Michael B., Seo Dong Joo, Anticancer Research: International Journal of Cancer Research and Treatment . 2018,第1期

机译：鞘氨醇诱导Pax3-FoxO1阳性肺泡骨髓瘤细胞中MyCN的细胞凋亡和下调，而无论TP53突变如何
2. TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells. [J] . Storz P, Doppler H, Horn-Muller J, Cell death and differentiation . 2000,第10期

机译：TNF受体酪氨酸激酶依赖的有丝分裂信号通路的TNF下调是诱导细胞停滞和Kym-1横纹肌肉瘤细胞凋亡的重要步骤。
3. Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells [J] . F Calhabeu, S Hayashi, J E Morgan, Oncogene . 2013,第5期

机译：肺泡横纹肌肉瘤相关蛋白PAX3 / FOXO1A和PAX7 / FOXO1A抑制肌肉干细胞中MyoD靶基因的转录活性
4. Degraded collagen fragments activate NF-kB and protect human smooth muscle cells against apoptosis through induction of inhibitor of apoptosis proteins (lAPs) [C] . K. von Wnuck Lipinski, N. Ferri, B. Levka Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：降解的胶原片段激活NF-KB并通过诱导凋亡蛋白抑制剂（圈）保护人平滑肌细胞免受细胞凋亡
5. Analysis of target genes regulated by the PAX3-FKHR oncoprotein associated with alveolar rhabdomyosarcoma [D] . Tomescu, Oana 2002

机译：PAX3-FKHR癌蛋白与肺泡横纹肌肉瘤相关基因调控的靶基因分析
6. Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins [O] . Michele Bernasconi, Andrew Remppis, William J. Fredericks, 1996

机译：通过诱导横纹肌肉瘤细胞凋亡 PAX蛋白的下调
7. PAX3-FOXO1 Induces Up-Regulation of Noxa Sensitizing Alveolar Rhabdomyosarcoma Cells to Apoptosis [O] . Amy D. Marshall, Fabrizio Picchione, Ramon I. Klein Geltink, 2013

机译：paX3-FOXO1诱导Noxa上调敏感性肺泡横纹肌肉瘤细胞凋亡
8. Differentiation, early response gene expression, and apoptosis induction in human breast tumor cells by Okadaic Acid and related inhibitors of protein phosphatases 1 and 2A. Okadaic acid effects on human breast tumor cells [R] . Kiguchi, K. , Giometti, C. , Chubb, C. H. , 1992

机译：冈田酸和蛋白磷酸酶1和2a的相关抑制剂在人乳腺肿瘤细胞中的分化，早期反应基因表达和凋亡诱导。冈田酸对人乳腺癌细胞的影响

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins

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