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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study
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Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

机译:一项基于法国社区的研究,研究老年人中硫酸脱氢表雄酮与功能,心理和精神状态以及短期死亡率的关系

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摘要

In human beings of both sexes, dehydroepi- androsterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50/100 higher in men than in women) decreases with age, toward ≈20-10/100 of its value in young adults during the 8th and 9th decades. The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor I, and effects on neu- rotransmitter receptors.
机译:在男女双方中,血液中循环的硫酸脱氢表雄酮硫酸盐(DHEAS)主要是肾上腺分泌的类固醇,其血清浓度(在微摩尔范围内,男性比女性高30-50 / 100)随着年龄的增长而降低,在第8和第9个十年中,其在年轻人中的价值的20-10 / 100。 DHEA和DHEAS的作用机理尚不清楚,可能包括部分转化为性类固醇,生物利用胰岛素样生长因子I的增加以及对神经递质受体的影响。

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