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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women.
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Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEAS), and memory in a longitudinal study of healthy elderly men and women.

机译：在健康的老年男性和女性的纵向研究中，皮质醇（CRT），硫酸脱氢表雄酮（DHEAS）和记忆之间的关系。

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At test times 18 months apart (Time 1 and Time 2), men (n Time 1 = 31, Time 2 = 23), women estrogen-users (n Time 1 = 14, Time 2 = 10), and women estrogen non-users (n Time 1 = 41, Time 2 = 27), whose average age was 72.1 and 73.4 years at Time 1 and Time 2, respectively, were tested with a battery of neuropsychological tests measuring verbal memory, visual memory, concentration/attention, language fluency and semantic memory. Plasma levels of CRT and DHEAS were assayed by radioimmunoassay at both test times. The men had higher DHEAS levels than both groups of women at both test times (p < 0.001) and also had a higher DHEAS/CRT ratio compared to the estrogen non-users (p < 0.05). Although there were no group differences in CRT levels at either time, CRT levels increased in the estrogen non-using women from Time 1 to Time 2 (p < 0.001). Subjects with lower CRT levels performed better than those with higher levels on several tests of declarative memory (p < 0.05). Men and estrogen-users had higher Digit Span scores compared to female estrogen non-users at both test times (p < 0.01), and women estrogen-users also had higher Backward Digit Span scores than non-users (p < 0.05). Both groups of women performed better than men on Category Retrieval (p < 0.01). These findings suggest that higher CRT levels in elderly men and women are associated with poorer explicit memory functioning; however, these results failed to provide any evidence that DHEAS is protective against declarative memory decline with aging.
机译：在相隔18个月的测试时间（时间1和时间2），男性（n时间1 = 31，时间2 = 23），女性雌激素使用者（n时间1 = 14，时间2 = 10）和女性非雌激素用户（n个时间1 = 41，时间2 = 27）分别在时间1和时间2的平均年龄分别为72.1岁和73.4岁，并接受了一系列神经心理学测试，包括语言记忆力，视觉记忆力，注意力/注意力，语言流利度和语义记忆。在两个测试时间通过放射免疫测定法测定血浆CRT和DHEAS的水平。与未使用雌激素的男性相比，在两次测试时间上，男性的DHEAS水平均高于两组女性（p <0.001），并且DHEAS / CRT比率也高于未使用雌激素的女性（p <0.05）。尽管这两种时间的CRT水平均无组间差异，但从1时到2时，未使用雌激素的女性的CRT水平升高（p <0.001）。在声明性记忆的几项测试中，具有较低CRT水平的受试者的表现优于具有较高水平的受试者（p <0.05）。在两个测试时间中，男性和雌激素使用者的数字跨度得分均高于女性雌激素使用者（p <0.01），女性雌激素使用者的反向数字跨度得分也高于非雌激素使用者（p <0.05）。两组女性在类别检索方面的表现均优于男性（p <0.01）。这些发现表明，老年男性和女性中较高的CRT水平与较差的显式记忆功能有关。但是，这些结果未能提供任何证据表明DHEAS可以防止声明性记忆随着年龄的增长而下降。

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