Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

Beatriz Goyenechea; Cesar Milstein

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Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

机译：修改免疫球蛋白V基因的序列会改变超突变的结果

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Affinity maturation of antibodies requires localized hypermutation and antigen selection. Hypermuta- tion is particularly active in certain regions (notably the CDRs of light and heavy chains) due to the local accumulation of hot spots. We have now analyzed the role of individual nucleotides in the origin of hot spots and show that mutability is largely defined by the nucleotide sequence. We compared the muta- bility profile of wild-type and modified k transgenes that contain silent mutations in the CDR1 segment.

机译：抗体的亲和力成熟需要局部超突变和抗原选择。由于热点的局部积累，超变在某些区域（尤其是轻链和重链的CDR）特别活跃。现在，我们已经分析了单个核苷酸在热点起源中的作用，并表明变异性在很大程度上由核苷酸序列决定。我们比较了在CDR1片段中含有沉默突变的野生型和修饰的k转基因的突变性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13979-13984|共6页
作者
Beatriz Goyenechea; Cesar Milstein;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID [J] . Meng Wang, Cristina Rada, Michael S. Neuberger The Journal of Experomental Medicine . 2010,第1期

机译：通过修改AID的活性位点来改变免疫球蛋白V基因体细胞超突变的光谱
2. Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein [J] . Kathleen Richter, Lauranell Burch, Frank Chao, The Journal of biological chemistry . 2012,第38期

机译：Slow-GC蛋白缺乏小鼠免疫球蛋白过度的改变模式
3. Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: Cell adhesion molecule from the living fossil spongeGeodia cydonium. Mapping of coherent database similarities and implications for evolution of CDR1 and hypermutation [J] . J. Kubrycht, J. Borecký, P. Souček, Folia Microbiologica . 2004,第3期

机译：蛋白激酶底物和抑制剂与免疫球蛋白和模型免疫球蛋白同源物的序列相似性：活化石海绵中的细胞粘附分子。一致数据库相似性的映射及其对CDR1和超突变进化的影响
4. Distributed discovery of asynchronous partial periodic patterns in sequence data using modified periodicity transform [C] . Han-Wen Hsiao, Meng-Shu Tsai, Tsai, . 2004

机译：使用修改的周期性变换分布式发现序列数据中的异步局部周期性模式
5. Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation. [D] . Rajagopal, Deepa. 2009

机译：免疫球蛋白切换mu序列引起RNA聚合酶II积累并减少dA超突变。
6. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation [O] . Beatriz Goyenechea, César Milstein 1996

机译：修饰免疫球蛋白V基因的序列会改变超变异的结果模式
7. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID [O] . Wang, Meng, Rada, Cristina, Neuberger, Michael S. 2010

机译：通过修改AID的活性位点来改变免疫球蛋白V基因体细胞超突变的光谱
8. Transfer of Colostral Immunoglobulin to Newborn Dairy Calves. Effects of Housingon Suckling Patterns and Consequences for the Intestinal Transmission of Macromolecules [R] . Michanek, P. 1994

机译：将初乳免疫球蛋白转移至新生乳牛犊。肠衣哺乳方式及其对大分子肠道传播的影响

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

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