Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O~6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

Jane S. Reese; Omer N. Ko?; Keun Myoung Lee

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O~6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

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Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O~6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

机译：逆转录病毒转导突变型甲基鸟嘌呤DNA甲基转移酶基因进入人CD34细胞赋予对O〜6-苄基鸟嘌呤加1,3-双（2-氯乙基）-1-亚硝基脲的抗性

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Human CD34 cells express low levels of the DNA repair protein O~6-alkylguanine-DNA alkyltransferase (AGT) and are sensitive to 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU). Gene transfer of the AGT gene, meth- ylguanine DNA methyltransferase (MGMT), results in only modest BCNU resistance. Recently, an AGT inhibitor, O~6- benzylguanine (BG), entered clinical trials. In preclinical studies, BG potentiated the cytotoxic effect of BCNU in tumors but increased toxicity to normal CD34 cells.

机译：人类CD34细胞表达低水平的DNA修复蛋白O〜6-烷基鸟嘌呤-DNA烷基转移酶（AGT），并对1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）敏感。 AGT基因（甲基鸟嘌呤DNA甲基转移酶（MGMT））的基因转移仅导致适度的BCNU抗性。最近，一种AGT抑制剂O〜6-苄基鸟嘌呤（BG）进入了临床试验。在临床前研究中，BG增强了BCNU在肿瘤中的细胞毒性作用，但增加了对正常CD34细胞的毒性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14088-14093|共6页
作者
Jane S. Reese; Omer N. Ko?; Keun Myoung Lee;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. UBIQUITINATION-DEPENDENT PROTEOLYSIS OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN HUMAN AND MURINE TUMOR CELLS FOLLOWING INACTIVATION WITH O-6-BENZYLGUANINE OR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA [J] . Srivenugopal KS, Yuan XH, Friedman HS, Biochemistry . 1996,第4期

机译：O-6-苄基鸟嘌呤或1,3-双（2-氯乙基）-1-硝基磺酰脲活化后，人和鼠肿瘤细胞中O-6-甲基鸟嘌呤-DNA甲基转移酶的泛化依赖性蛋白水解
2. UBIQUITINATION-DEPENDENT PROTEOLYSIS OF O-6-METHYLGUANINE-DNA METHYLTRANSFERASE IN HUMAN AND MURINE TUMOR CELLS FOLLOWING INACTIVATION WITH O-6-BENZYLGUANINE OR 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA [J] . Srivenugopal KS, Yuan XH, Friedman HS, Biochemistry . 1996,第4期

机译：O-6-苄基鸟嘌呤或1,3-双（2-氯乙基）-1-硝基磺酰脲活化后，人和鼠肿瘤细胞中O-6-甲基鸟嘌呤-DNA甲基转移酶的泛化依赖性蛋白水解
3. Contribution of O6-methylguanine-DNA methyltransferase to resistance to 1,3-(2-chloroethyl)-1-nitrosourea in human brain tumor-derived cell lines. [J] . Bobola MS, Berger MS, Silber JR Molecular Carcinogenesis . 1995,第2期

机译：O6-甲基鸟嘌呤-DNA甲基转移酶对人脑肿瘤衍生细胞系对1,3-（2-氯乙基）-1-亚硝基脲的抗性的贡献。
4. Structural Characterization of the DNA Adducts Induced by 1,3-Bis-(2-Chloroethyl)-1-Nitrosourea Using Electrospray Ionization Tandem Mass Spectrometry [C] . Bai Bao-Qing, Zhao Li-Jiao, Zhong Ru-Gang 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：1,3-双-（2-氯乙基）-1-硝基硫脲诱导的DNA加合物的电喷雾串联质谱表征
5. Retroviral transduction of mutant O6-methylguanine-DNA methyltransferase as a potent selection factor in hematopoietic stem cells in mouse models. [D] . Davis, Brian Michael. 2000

机译：逆转录病毒转导的突变O6-甲基鸟嘌呤-DNA甲基转移酶作为小鼠模型中造血干细胞的有效选择因子。
6. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 13-bis(2-chloroethyl)-1-nitrosourea [O] . Jane S. Reese, Omer N. Koç, Keun Myoung Lee, 1996

机译：逆转录病毒转导突变体甲基鸟嘌呤DNA 甲基转移酶基因进入人CD34细胞赋予抗性 O6-苄基鸟嘌呤加13-双（2-氯乙基）-1-亚硝基脲
7. Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea [O] . J. S. Reese, O. N. Koc, K. M. Lee, 1996

机译：将突变体甲基叶碱DNA甲基转移酶基因转导入人CD34细胞的逆转录病毒转导赋予O6-苄基致抗1,3-双（2-氯乙基）-1-亚硝基脲

Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O~6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea

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