Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation

Donald C. Malins; Nayak L. Polissar; Sandra J. Gunselman

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Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation

机译：肿瘤进展至转移状态涉及DNA的结构修饰，该修饰与原发性肿瘤形成明显不同

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Wavenumber-absorbance relationships of infrared spectra of DNA analyzed by principal components analysis may be expressed as points in space. Each point represents a highly discriminating measure of DNA structure. Structural modifications of DNA, such as those induced by free radicals, alter vibrational and rotational motion and consequently change the spatial location of the points.

机译：通过主成分分析法分析的DNA的红外光谱的波数-吸光度关系可以表示为空间中的点。每个点代表对DNA结构的高度区分性度量。 DNA的结构修饰（例如由自由基诱导的修饰）会改变振动和旋转运动，从而改变这些点的空间位置。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.14047-14052|共6页
作者
Donald C. Malins; Nayak L. Polissar; Sandra J. Gunselman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation [O] . Donald C. Malins, Nayak L. Polissar, Sandra J. Gunselman 1996

机译：肿瘤进展至转移状态涉及结构 DNA中的修饰与与原发性肿瘤形成
7. Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation [O] . D. C. Malins, N. L. Polissar, S. J. Gunselman 1996

机译：转移状态的肿瘤进展涉及DNA中的结构修饰与与原发性肿瘤形成相关的DNA
8. Investigations of Functional and Structural Interactions Between c-src and HER2: Involvement in Human Breast Tumor Formation [R] . Belches, A. P. , Parsons, S. J. 1999

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Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation

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