Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

Eric D. Werner; effrey L. Brodsky; Ardythe A. McCracken

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Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

机译：蛋白酶体依赖性内质网相关蛋白降解：通向命运的非常规途径

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Until recently, the degradation of aberrant and unassembled proteins retained in the endoplasmic retic- ulum (ER) was thought to involve unidentified ER-localized proteases. We now show that the ER-associated degradation (ERAD) of two mutant proteins that accumulate in the ER lumen is inhibited in a proteasome-defective yeast strain and when cytosol from this mutant is used in an in vitro assay. In addition, ERAD is limited in vitro in the presence of the proteasome inhibitors, 3,4-dichloroisocoumarin and lactacystin.

机译：直到最近，内质网（ER）中保留的异常蛋白和未组装蛋白的降解还被认为与未鉴定的ER定位蛋白酶有关。我们现在显示，在蛋白酶体缺陷型酵母菌株中，当来自该突变体的胞质溶胶用于体外测定时，两种在ER内腔中积累的突变蛋白的ER相关降解（ERAD）被抑制。另外，ERAD在蛋白酶体抑制剂3，4-二氯异香豆素和乳腺素的存在下在体外受到限制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第24期|p.13797-13801|共5页
作者
Eric D. Werner; effrey L. Brodsky; Ardythe A. McCracken;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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6. Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate [O] . Eric D. Werner, Jeffrey L. Brodsky, Ardythe A. McCracken 1996

机译：蛋白酶体依赖性内质网相关蛋白退化：通向命运的非常规途径
7. Endoplasmic Reticulum Degradation-Enhancing α-Mannosidase-like Protein 1 Targets Misfolded HLA-B27 Dimers for Endoplasmic Reticulum-Associated Degradation [O] . Guiliano, David B., Fussell, Helen, Lenart, Izabela, 2014

机译：内质网降解增强α-甘露糖苷酶样蛋白1靶向错误折叠的HLA-B27二聚体，用于内质网相关降解

Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate

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