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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The AML1/ETO fusion protein activates transcription of BCL-2
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The AML1/ETO fusion protein activates transcription of BCL-2

机译:AML1 / ETO融合蛋白激活BCL-2的转录

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摘要

The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize the same Consensus DNA-binding motif (TGT/CGGT) which is found In the promoters of several genes involved in hematopoiesis.
机译:AML1基因位于21号染色体上,与人类白血病中几种明显的染色体易位有关。在t(8; 21)急性骨髓性白血病(AML)中,AML1基因与位于8号染色体上的ETO基因并列,生成AML1 / ETO融合蛋白。 AML1 / ETO和AML1蛋白都识别相同的共识DNA结合基序(TGT / CGGT),这是在涉及造血作用的几个基因的启动子中发现的。

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