Schizandrin B relieves repression of NF1 tumor suppressor by the AML1-ETO fusion protein

机译：Schizandrin B通过AML1-ETO融合蛋白抑制NF1肿瘤抑制剂的抑制

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

Schizandrin B isolated from the fruit of Schisandra chinensis, has been reported as an anti-cancer substance. In this study, we investigated the effects of Schizandrin B on the tumor suppressor gene NF1 in AMLl-ETO-expressing cell lines. We found thatAMLl-ETO-expressing cell lines displayed a low level of NF1 gene. Chromatin immunoprecipitation assays demonstrated that NF1 was the direct transcriptional target of AML1-ETO. The universal binding of AML1-ETO to genomic DNA resulted in recruitment of methyl-CpG binding protein 2 (MeCP2), indicating that AML1-ETO induced heterochromatic silencing of NFL Our findings indicate that Schizandrin B can relieve NF1 suppression in AMLl-ETO-expressing cells through a mechanism that involves inversion of epigenetic alterations.

机译：据据报道，从Schisandra chinensis果实中分离出抗癌物质。在这项研究中，我们研究了Schizandrin B对表达肿瘤抑制基因NF1的肿瘤抑制基因NF1的影响。我们发现表达AmMl-Eto表达的细胞系显示出低水平的NF1基因。染色质免疫沉淀测定证明NF1是AML1-ETO的直接转录靶标。 AML1-eTO对基因组DNA的通用结合导致甲基-CPG结合蛋白2（MECP2）募集，表明AML1-ETO诱导NFL的异色沉默我们的研究结果表明Schizandrin B可以缓解AMLL-ETO表达的NF1抑制细胞通过涉及表观遗传改变的反演的机制。

著录项

来源
《International Conference on Food Hygiene, Agriculture and Animal Science》|2016年|xiv 305 p. :|共7页
会议地点
作者
Wen-Yue Zhuang; Jian-Guang Chen;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TS207-532;
关键词
Schizandrin B; NF1; AML1-ETO;

机译：shizandrin;nf1;atl1是;

相似文献

外文文献
中文文献
专利

1. Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t(8;21) Fusion Protein [J] . Genyan Yang, Waleed Khalaf, Louis van de Locht, Molecular and Cellular Biology . 2005,第14期

机译：t（8; 21）融合蛋白对神经纤维瘤病1肿瘤抑制子的转录抑制
2. NF1 Tumor Suppressor Protein and mRNA in Skeletal Tissues of Developing and Adult Normal Mouse and NF1-Deficient Embryos. [J] . Kuorilehto T, Nissinen M, Koivunen J, Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2004,第6期

机译：发育中和成年正常小鼠和NF1缺陷胚胎的骨骼组织中的NF1肿瘤抑制蛋白和mRNA。
3. Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis [J] . Maria Malminen, Sirkku Peltonen, Jussi Koivunen, BMC Dermatology . 2002,第1期

机译：NF1肿瘤抑制蛋白的功能表达：在人类表皮早期发育过程中与角蛋白中间丝相关
4. Schizandrin B relieves repression of NF1 tumor suppressor by the AML1-ETO fusion protein [C] . Wen-Yue Zhuang, Jian-Guang Chen International Conference on Food Hygiene, Agriculture and Animal Science . 2016

机译：Schizandrin B通过AML1-ETO融合蛋白抑制NF1肿瘤抑制剂的抑制
5. Investigating the p53-mdm2-ARF signaling circuit: Repression of ARF by the p53 tumor suppressor protein, oncogene activation of ARF, and detection of p53 activity in living cells [D] . Walsh, Christine A. 2006

机译：研究p53-mdm2-ARF信号回路：p53抑癌蛋白抑制ARF，ARF的癌基因激活以及活细胞中p53活性的检测
6. Transcriptional Repression of the Neurofibromatosis-1 Tumor Suppressor by the t(8;21) Fusion Protein [O] . Genyan Yang, Waleed Khalaf, Louis van de Locht, 2005

机译：t（8; 21）融合蛋白对神经纤维瘤病1肿瘤抑制因子的转录抑制
7. Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein [O] . Yang Genyan, Khalaf Waleed, van de Locht Louis, 2005

机译：t（8; 21）融合蛋白对神经纤维瘤1肿瘤抑制因子的转录抑制

Schizandrin B relieves repression of NF1 tumor suppressor by the AML1-ETO fusion protein

摘要

著录项

相似文献

相关主题

期刊订阅